{"id":100777,"date":"2025-04-14T16:28:18","date_gmt":"2025-04-14T15:28:18","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/un-tipo-de-celula-inmune-es-clave-para-entender-las-alergias-alimentarias\/"},"modified":"2025-04-14T16:28:18","modified_gmt":"2025-04-14T15:28:18","slug":"un-tipo-de-celula-inmune-es-clave-para-entender-las-alergias-alimentarias","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/un-tipo-de-celula-inmune-es-clave-para-entender-las-alergias-alimentarias\/","title":{"rendered":"Un tipo de c\u00e9lula inmune es clave para entender las alergias alimentarias"},"content":{"rendered":"

Un estudio, liderado por investigadores de NYU Langone Health (EE UU), revela que un grupo especial de c\u00e9lulas en los intestinos reducen la respuesta inmune causada por la exposici\u00f3n a las prote\u00ednas de los alimentos: las llamadas\u00a0c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas<\/a>. Estas c\u00e9lulas permiten que los alimentos pasen a trav\u00e9s del cuerpo sin desencadenar una reacci\u00f3n inmune. Sin embargo, la investigaci\u00f3n dio como resultado que en aquellos ratones que funcionaban mal, causaban alergias alimentarias y asma.<\/p>\n

Un trabajo previo de este mismo equipo hab\u00eda revelado que estas mismas c\u00e9lulas controlan la tolerancia inmune a las bacterias intestinales, que ayudan a los humanos a digerir los alimentos y a controlar las funciones de m\u00faltiples sistemas de \u00f3rganos. Pero se sab\u00eda muy poco si controlaban otras tolerancias.<\/p>\n

<\/p>\n

Las c\u00e9lulas dendriticas que expresan ROR-express son componentes clave en la respuesta regulatoria inmunitaria que previene las alergias alimentaria<\/p>\n

Dan Littman, autor principal
\n<\/p>\n

\u201cNuestro estudio muestra que las c\u00e9lulas dendriticas que expresan ROR-express son componentes clave en la respuesta regulatoria inmunitaria que previene las alergias alimentarias\u201d, apunta el autor principal del estudio Dan Littman, junto a Helen L. y Martin S. Kimmel de la Escuela de Medicina Grossman de la NYU.<\/p>\n

<\/a><\/p>\n

Mantiener el equilibrio en el microbioma<\/h2>\n

Las c\u00e9lulas dendr\u00edticas presentan peque\u00f1os fragmentos de material biol\u00f3gico (conocidos como ant\u00edgenos) para recibir atenci\u00f3n por otras c\u00e9lulas inmunitarias llamadas c\u00e9lulas T. Esto programa la c\u00e9lula T para lanzar un ataque inmune la siguiente vez que encuentre el ant\u00edgeno.<\/p>\n

Los investigadores demostraron que cuando las c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas presentan ant\u00edgenos de alimentos o microbios amigables a las c\u00e9lulas T, dichas c\u00e9lulas T se vuelven antiinflamatorias, o regulatorias. Esto implica que cuando se encuentre con el ant\u00edgeno, en lugar de atacar, suprimir\u00e1 la inflamaci\u00f3n cercana.<\/p>\n

Los investigadores observaron que en ratones sin c\u00e9lulas dendr\u00edticas toler\u00f3genas, hab\u00eda menos c\u00e9lulas T regulatorias listas para prevenir la inflamaci\u00f3n causada por alimentos<\/p>\n

Los investigadores observaron que en ratones sin c\u00e9lulas dendr\u00edticas toler\u00f3genas, hab\u00eda menos c\u00e9lulas T regulatorias listas para prevenir la inflamaci\u00f3n causada por alimentos o ant\u00edgenos microbianos. Esos ratones tambi\u00e9n ten\u00edan m\u00e1s c\u00e9lulas T inflamatorias que causaban alergias e inflamaci\u00f3n cuando se expon\u00edan a esos ant\u00edgenos.<\/p>\n

<\/a><\/p>\n

M\u00e1s informaci\u00f3n para tratar alergias<\/h2>\n

Otro hallazgo clave del trabajo fue que, al analizar el tejido intestinal humano y los conjuntos de datos de secuenciaci\u00f3n conocidos, encontraron los equivalentes humanos de las c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas.<\/p>\n

<\/p>\n

Si otros experimentos resultan exitosos, nuestros hallazgos podr\u00edan conducir a formas innovadoras de tratar las alergias alimentarias<\/p>\n

Dan Littman
\n<\/p>\n

\u201cSi otros experimentos resultan exitosos, nuestros hallazgos podr\u00edan conducir a formas innovadoras de tratar las alergias alimentarias\u201d, destaca Littman. Por ejemplo, si alguien tiene una alergia al cacahuete, tal vez podamos usar c\u00e9lulas dendriticas tolerog\u00e9nicas para ayudar a crear m\u00e1s c\u00e9lulas T regulatorias para suprimir una respuesta al\u00e9rgica a las mol\u00e9culas de dicha legumbre\u201d, concluye.<\/p>\n

Referencia:<\/p>\n

Dan Littman, Helen L. y Martin S. Kimmel. \u201cPrdm16-dependent antigen-presenting cells induce tolerance to gut antigens\u201d.\u00a0Nature<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Un estudio, liderado por investigadores de NYU Langone Health (EE UU), revela que un grupo especial de c\u00e9lulas en los intestinos reducen la respuesta inmune causada por la exposici\u00f3n a las prote\u00ednas de los alimentos: las llamadas\u00a0c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas. Estas c\u00e9lulas permiten que los alimentos pasen a trav\u00e9s del cuerpo sin desencadenar una reacci\u00f3n inmune. […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-100777","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nUn tipo de c\u00e9lula inmune es clave para entender las alergias alimentarias - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/un-tipo-de-celula-inmune-es-clave-para-entender-las-alergias-alimentarias\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un tipo de c\u00e9lula inmune es clave para entender las alergias alimentarias\" \/>\n<meta property=\"og:description\" content=\"Un estudio, liderado por investigadores de NYU Langone Health (EE UU), revela que un grupo especial de c\u00e9lulas en los intestinos reducen la respuesta inmune causada por la exposici\u00f3n a las prote\u00ednas de los alimentos: las llamadas\u00a0c\u00e9lulas dendr\u00edticas tolerog\u00e9nicas. 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