{"id":114769,"date":"2025-05-06T11:28:22","date_gmt":"2025-05-06T10:28:22","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/la-falta-de-una-proteina-inicia-el-cancer-de-colon-en-ratones\/"},"modified":"2025-05-06T11:28:22","modified_gmt":"2025-05-06T10:28:22","slug":"la-falta-de-una-proteina-inicia-el-cancer-de-colon-en-ratones","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/la-falta-de-una-proteina-inicia-el-cancer-de-colon-en-ratones\/","title":{"rendered":"La falta de una prote\u00edna inicia el c\u00e1ncer de colon en ratones"},"content":{"rendered":"

El c\u00e1ncer colorrectal es el tercer tipo de tumor maligno m\u00e1s diagnosticado en todo el mundo, y hasta el 80 % de los casos se relacionan con factores ambientales y de estilo de vida.<\/p>\n

Una reciente investigaci\u00f3n, publicada en Nature Communications, demuestra la existencia de un mecanismo molecular por el cual se inicia la formaci\u00f3n de tumores agresivos en el col\u00f3n. El estudio, liderado por el Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), lo achaca a la falta de la prote\u00edna p53, capaz de inhibir la divisi\u00f3n celular.<\/p>\n

La\u00a0p53\u00a0es conocida bloquea la divisi\u00f3n de las c\u00e9lulas y contribuye a que se destruyan cuando presentan alguna disfunci\u00f3n<\/p>\n

En investigaciones con ratones, los autores observaron que esta prote\u00edna se empezaba a degradar \u2013a disminuir su presencia\u2013 en las etapas iniciales de la formaci\u00f3n de los tumores. Esto permit\u00eda la aparici\u00f3n y el desarrollo del c\u00e1ncer.<\/p>\n

<\/a><\/p>\n

Crecer de forma descontrolada<\/h2>\n

La funci\u00f3n antitumoral de la p53 es conocida. Esta prote\u00edna bloquea la divisi\u00f3n de las c\u00e9lulas y contribuye a que se destruyan cuando presentan alguna disfunci\u00f3n, por lo que se considera supresora de tumores.<\/p>\n

Cuando esta mol\u00e9cula pierde su funci\u00f3n, las c\u00e9lulas adquieren la capacidad de crecer de manera descontrolada.<\/p>\n

La primera autora de este estudio, Irene Herranz-Montoya, explica que la escasez de p53 ayuda a la formaci\u00f3n del tumor debido a un descontrol celular, y tambi\u00e9n facilita que las c\u00e9lulas acumulen otras mutaciones que impulsen la progresi\u00f3n a tumores m\u00e1s agresivos.<\/p>\n

Adem\u00e1s, el grupo del CNIO identific\u00f3 un mecanismo in\u00e9dito en la regulaci\u00f3n de los niveles de p53. Se trata de una prote\u00edna denominada URI, conocida por su expresi\u00f3n en otros tipos de c\u00e1ncer. Al aumentar los niveles de URI en las c\u00e9lulas, disminuye la p53.<\/p>\n

<\/a><\/p>\n

La prote\u00edna URI<\/h2>\n

Anteriormente, otros cient\u00edficos hab\u00edan relacionado la prote\u00edna URI con otros tipos de c\u00e1ncer, sobre todo con el de h\u00edgado, pero esta es la primera vez que se asocia URI a tumores colorrectales.<\/p>\n

\u201cLos niveles de URI comienzan a elevarse muy al principio, lo que conduce a la formaci\u00f3n del adenoma \u2013 un crecimiento aberrante \u2013 que a\u00fan no constituye un c\u00e1ncer, pero es en esa etapa donde empieza a degradarse la p53\u201d, explica Herranz-Montoya.<\/p>\n

Vieron que si eliminaban URI o elevaban los niveles de p53 en los p\u00f3lipos no llegaban a transformarse en tumores y los ratones con c\u00e1ncer colorrectal\u00a0viv\u00edan m\u00e1s tiempo<\/p>\n

En sus experimentos en ratones vieron que, si eliminaban URI o elevaban los niveles de p53 en los p\u00f3lipos, estos no llegaban a transformarse en tumores y los ratones con c\u00e1ncer colorrectal viv\u00edan m\u00e1s tiempo.<\/p>\n

\u00abSi nos centramos en investigar los mecanismos moleculares que provocan la degradaci\u00f3n de p53, entre ellos el incremento de URI, podr\u00edamos en un futuro intervenir en los estadios iniciales del c\u00e1ncer y prevenir su progresi\u00f3n a formas m\u00e1s agresivas de la enfermedad\u201d, afirma Herranz-Montoya.<\/p>\n

Con este objetivo, el equipo enfoca ahora su trabajo en el desarrollo de\u00a0inhibidores de la prote\u00edna URI.<\/p>\n

<\/a><\/p>\n

Estilo de vida y dieta<\/h2>\n

Por su parte el l\u00edder del proyecto Nabil Djouder se\u00f1ala que este nuevo mecanismo podr\u00eda arrojar luz las posibles causas del aumento del c\u00e1ncer colorrectal en adultos j\u00f3venes, en relaci\u00f3n con factores ambientales y estilos de vida.<\/p>\n

\u201cMi equipo ha demostrado que la expresi\u00f3n de URI est\u00e1 relacionada con ciertos factores ambientales, como una mala dieta, tanto en otros tipos de c\u00e1ncer como en el intestino\u201d, explica Djouder.<\/p>\n

La progresiva disminuci\u00f3n de la prote\u00edna p53 ocurre de manera independiente a otro proceso que ya se conoc\u00eda: la p\u00e9rdida del gen\u00a0TP53<\/p>\n

Por otro lado, la progresiva disminuci\u00f3n de la prote\u00edna p53 ocurre de manera independiente a otro proceso que ya se conoc\u00eda: la p\u00e9rdida del gen TP53 \u2013el que codifica la prote\u00edna p53\u2013 en estadios tard\u00edos del c\u00e1ncer colorrectal.<\/p>\n

Ambos procesos influyen en el c\u00e1ncer de forma paralela: la degradaci\u00f3n de la prote\u00edna en las\u00a0fases iniciales, y la p\u00e9rdida del gen en etapas m\u00e1s avanzadas en contexto de met\u00e1stasis.<\/p>\n

Referencia:\u00a0<\/p>\n

Herranz- Montoya, I. P53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer. Nature Commmunication<\/a>. 2025<\/p>","protected":false},"excerpt":{"rendered":"

El c\u00e1ncer colorrectal es el tercer tipo de tumor maligno m\u00e1s diagnosticado en todo el mundo, y hasta el 80 % de los casos se relacionan con factores ambientales y de estilo de vida. Una reciente investigaci\u00f3n, publicada en Nature Communications, demuestra la existencia de un mecanismo molecular por el cual se inicia la formaci\u00f3n […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-114769","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nLa falta de una prote\u00edna inicia el c\u00e1ncer de colon en ratones - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/la-falta-de-una-proteina-inicia-el-cancer-de-colon-en-ratones\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La falta de una prote\u00edna inicia el c\u00e1ncer de colon en ratones\" \/>\n<meta property=\"og:description\" content=\"El c\u00e1ncer colorrectal es el tercer tipo de tumor maligno m\u00e1s diagnosticado en todo el mundo, y hasta el 80 % de los casos se relacionan con factores ambientales y de estilo de vida. 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