{"id":116138,"date":"2025-05-08T10:28:24","date_gmt":"2025-05-08T09:28:24","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/la-proteina-klotho-prolonga-la-esperanza-de-vida\/"},"modified":"2025-05-08T10:28:24","modified_gmt":"2025-05-08T09:28:24","slug":"la-proteina-klotho-prolonga-la-esperanza-de-vida","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/la-proteina-klotho-prolonga-la-esperanza-de-vida\/","title":{"rendered":"La prote\u00edna klotho prolonga la esperanza de vida"},"content":{"rendered":"<p>Con la edad, es natural que perdamos masa muscular y \u00f3sea, lo que conlleva un aumento de la debilidad, que puede derivar en ca\u00eddas y lesiones importantes.<\/p>\n<p>Adem\u00e1s, a nivel cognitivo, las neuronas se degeneran progresivamente y pierden conexiones, a la vez que aumenta la prevalencia de enfermedades como el alzh\u00e9imer o el p\u00e1rkinson. En una sociedad cada vez m\u00e1s envejecida, mitigar estos efectos es uno de los principales retos de la investigaci\u00f3n.<\/p>\n<p>Ahora, en un art\u00edculo publicado en la revista\u00a0Molecular Therapy, un equipo de investigaci\u00f3n internacional liderado por el profesor Miguel Chill\u00f3n, investigador ICREA en el INc-UAB, ha demostrado que aumentar los niveles de la prote\u00edna klotho en su forma secretada (s-KL) mejora el envejecimiento en ratones.<\/p>\n<p>Los ratones tratados con s-KL mostraban un mejor rendimiento f\u00edsico, una mayor capacidad de regeneraci\u00f3n muscular y menos fibrosis<\/p>\n<p>El equipo trat\u00f3 a animales j\u00f3venes con vectores de terapia g\u00e9nica para que sus c\u00e9lulas secretaran m\u00e1s s-KL. A los 24 meses de edad, equivalentes a unos setenta a\u00f1os en humanos, comprobaron que el tratamiento hab\u00eda mejorado la salud muscular, \u00f3sea y cognitiva de los animales.<\/p>\n<p>\u201cLlevamos tiempo trabajando con la prote\u00edna klotho por su potencial terap\u00e9utico para tratar enfermedades neurodegenerativas. En este estudio quer\u00edamos comprobar si s-KL tambi\u00e9n pod\u00eda ser beneficiosa para un envejecimiento saludable, analizando un amplio abanico de aspectos\u201d, explica Miguel Chill\u00f3n.<\/p>\n<p><a><\/a><\/p>\n<h2>Resultados del estudio<\/h2>\n<p>Los ratones tratados con s-KL vivieron entre un 15 %\u00a0y un 20\u00a0% m\u00e1s y mostraban un mejor rendimiento f\u00edsico, una mayor capacidad de regeneraci\u00f3n muscular y menos fibrosis, factores que indican una mejor salud muscular.<\/p>\n<p>Tambi\u00e9n se observaron mejoras en la salud \u00f3sea, especialmente en las hembras, con una mayor preservaci\u00f3n de la estructura interna de los huesos (las trab\u00e9culas), lo que sugiere una posible protecci\u00f3n contra la osteoporosis.<\/p>\n<p>Finalmente, en el cerebro, el tratamiento con s-KL favoreci\u00f3 la generaci\u00f3n de nuevas neuronas y aument\u00f3 la actividad inmunitaria en el hipocampo, lo que indica posibles beneficios cognitivos.<\/p>\n<p>El tratamiento con vectores virales consiste en introducir en las c\u00e9lulas del cuerpo copias del gen de la prote\u00edna que se quiere producir, de modo que empiecen a fabricarla de forma aut\u00f3noma. En los ratones, estos vectores se administraron por v\u00eda intravenosa y cerebral para asegurar que las c\u00e9lulas del cerebro tambi\u00e9n produjeran s-KL.<\/p>\n<p>El tratamiento con s-KL favoreci\u00f3 la generaci\u00f3n de nuevas neuronas y aument\u00f3 la actividad inmunitaria en el hipocampo<\/p>\n<p>\u201cActualmente se han desarrollado vectores que llegan al cerebro tras administrarse por v\u00eda intravenosa, lo que facilitar\u00eda trasladar esta terapia a humanos de forma segura\u201d,\u00a0explica Joan Roig-Soriano, investigador del INc-UAB y primer autor del art\u00edculo.<\/p>\n<p>\u201cOtra opci\u00f3n ser\u00eda administrar directamente la prote\u00edna como un f\u00e1rmaco, en lugar de usar vectores virales, pero todav\u00eda hay que encontrar la forma m\u00e1s eficiente de administrarla y lograr que llegue a los \u00f3rganos diana\u201d, a\u00f1ade.<\/p>\n<p>El grupo de investigaci\u00f3n ya hab\u00eda patentado el uso de klotho para tratar d\u00e9ficits cognitivos y, tras este trabajo, han generado\u00a0tres nuevas patentes. Estas patentes protegen el uso de Klotho para tratar d\u00e9ficits \u00f3seos y musculares, as\u00ed como para desarrollar terapias que aumenten la longevidad.<\/p>\n<p>\u201cSi se consigue encontrar una forma viable de administraci\u00f3n, s-KL podr\u00eda contribuir de forma significativa a mejorar la calidad de vida de las personas y a lograr una sociedad lo m\u00e1s saludable posible\u201d, destacan los investigadores.<\/p>\n<p>Referencia:<\/p>\n<p>Roig-Soriano, J. et. al. \u201cEfectos a largo plazo del tratamiento con s-KL en ratones de tipo salvaje: mejora de la longevidad, el bienestar f\u00edsico y la resistencia neurol\u00f3gica\u201d.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.ymthe.2025.02.030\" target=\"_blank\">Terapia molecular <\/a>(2025)<\/p>","protected":false},"excerpt":{"rendered":"<p>Con la edad, es natural que perdamos masa muscular y \u00f3sea, lo que conlleva un aumento de la debilidad, que puede derivar en ca\u00eddas y lesiones importantes. Adem\u00e1s, a nivel cognitivo, las neuronas se degeneran progresivamente y pierden conexiones, a la vez que aumenta la prevalencia de enfermedades como el alzh\u00e9imer o el p\u00e1rkinson. En [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-116138","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.9 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>La prote\u00edna klotho prolonga la esperanza de vida - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/la-proteina-klotho-prolonga-la-esperanza-de-vida\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La prote\u00edna klotho prolonga la esperanza de vida\" \/>\n<meta property=\"og:description\" content=\"Con la edad, es natural que perdamos masa muscular y \u00f3sea, lo que conlleva un aumento de la debilidad, que puede derivar en ca\u00eddas y lesiones importantes. 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