{"id":165128,"date":"2025-07-30T11:33:37","date_gmt":"2025-07-30T10:33:37","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/safety-and-efficacy-of-the-feed-additives-l%e2%80%90histidine-and-l%e2%80%90histidine-monohydrochloride-monohydrate-produced-with-corynebacterium-glutamicum-kccm-80389-for-all-animal-species-cj-europ\/"},"modified":"2025-07-30T11:33:37","modified_gmt":"2025-07-30T10:33:37","slug":"safety-and-efficacy-of-the-feed-additives-l%e2%80%90histidine-and-l%e2%80%90histidine-monohydrochloride-monohydrate-produced-with-corynebacterium-glutamicum-kccm-80389-for-all-animal-species-cj-europ","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/safety-and-efficacy-of-the-feed-additives-l%e2%80%90histidine-and-l%e2%80%90histidine-monohydrochloride-monohydrate-produced-with-corynebacterium-glutamicum-kccm-80389-for-all-animal-species-cj-europ\/","title":{"rendered":"Safety and efficacy of the feed additives l\u2010histidine and l\u2010histidine monohydrochloride monohydrate produced with Corynebacterium glutamicum KCCM 80389 for all animal species (CJ Europe GmbH) AUTORIDAD EUROPEA DE SEGURIDAD ALIMENTARIA: SUBVENCIONES\/NOTICIAS\/ADQUISCIONES"},"content":{"rendered":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l\u2010histidine and l\u2010histidine monohydrochloride monohydrate produced with a genetically modified strain of Corynebacterium glutamicum (KCCM 80389) as nutritional and sensory feed additives for all animal species and categories. l\u2010Histidine and l\u2010histidine monohydrochloride monohydrate manufactured by fermentation with C. glutamicum KCCM 80389 do not give rise to any safety concern regarding the genetic modifications of the production strain. No viable cells or DNA of the production strain were detected in the final products. The FEEDAP Panel concluded that the use of l\u2010histidine and l\u2010histidine monohydrochloride monohydrate produced with C. glutamicum KCCM 80389 in feed raises no safety concerns for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the species. The FEEDAP Panel had concerns on the use of l\u2010histidine and l\u2010histidine monohydrochloride monohydrate in water for drinking. The FEEDAP Panel concluded that the use of l\u2010histidine and l\u2010histidine monohydrochloride monohydrate produced by fermentation with C. glutamicum KCCM 80389 in animal nutrition are safe for the consumers of products from animals receiving the additive, and to the environment. Regarding the user safety, the additives are not considered irritant to skin or eyes and are not considered potential skin sensitisers. The additives were regarded as effective sources of the amino acid l\u2010histidine for all non\u2010ruminant species. To be as efficacious in ruminants as in non\u2010ruminants, it should be protected from ruminal degradation.<\/p>","protected":false},"excerpt":{"rendered":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l\u2010histidine and l\u2010histidine monohydrochloride monohydrate produced with a genetically modified strain of Corynebacterium glutamicum (KCCM 80389) as nutritional and sensory feed additives for all animal species and categories. l\u2010Histidine and l\u2010histidine monohydrochloride monohydrate manufactured 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