{"id":180592,"date":"2025-09-04T10:28:14","date_gmt":"2025-09-04T09:28:14","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/la-activacion-del-tejido-adiposo-marron-mediante-la-proteina-neuritina-1-protege-frente-a-la-obesidad\/"},"modified":"2025-09-04T10:28:14","modified_gmt":"2025-09-04T09:28:14","slug":"la-activacion-del-tejido-adiposo-marron-mediante-la-proteina-neuritina-1-protege-frente-a-la-obesidad","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/la-activacion-del-tejido-adiposo-marron-mediante-la-proteina-neuritina-1-protege-frente-a-la-obesidad\/","title":{"rendered":"La activaci\u00f3n del tejido adiposo marr\u00f3n mediante la prote\u00edna neuritina 1 protege frente a la obesidad"},"content":{"rendered":"

\u00bfEs posible tratar la obesidad sin reducir la ingesta alimentaria? Un nuevo estudio del Instituto de Investigaci\u00f3n Biom\u00e9dica (IRB Barcelona) apunta que, al menos en modelos de rat\u00f3n, s\u00ed lo es.<\/p>\n

El trabajo, publicado en la revista Nature Communications y liderado\u00a0por Antonio Zorzano\u00a0y\u00a0Manuela S\u00e1nchez-Feutrie, del IRB, revela que la\u00a0neuritina 1, una prote\u00edna hasta ahora vinculada al sistema nervioso, tambi\u00e9n se produce en el tejido adiposo marr\u00f3n. All\u00ed act\u00faa como un potente activador del gasto energ\u00e9tico y protege frente a la obesidad y otras enfermedades metab\u00f3licas.<\/p>\n

La\u00a0neuritina 1, una prote\u00edna vinculada al sistema nervioso, tambi\u00e9n se produce en el tejido adiposo marr\u00f3n, seg\u00fan el estudio del IRB<\/p>\n

A diferencia de los f\u00e1rmacos actuales contra la obesidad y la diabetes, como Ozempic o tirzepatida, que reducen el apetito, la neuritina 1 incrementa el consumo de energ\u00eda sin alterar la conducta alimentaria.<\/p>\n

<\/a><\/p>\n

M\u00e1s energ\u00eda y menos grasa<\/h2>\n

\u201cLo que hemos observado es que, al aumentar la expresi\u00f3n de neuritina espec\u00edficamente en el tejido adiposo marr\u00f3n, los ratones consumen m\u00e1s energ\u00eda, lo que impide la acumulaci\u00f3n de grasa\u201d, explica Zorzano, tambi\u00e9n catedr\u00e1tico de la Universidad de Barcelona e investigador del CIBERDEM.<\/p>\n

Este aumento del metabolismo se traduce en mejoras como menor ganancia de peso, mayor sensibilidad a la insulina y menor inflamaci\u00f3n hep\u00e1tica, incluso en dietas hipercal\u00f3ricas<\/p>\n

Este aumento del metabolismo se traduce en mejoras significativas: menor ganancia de peso, mayor sensibilidad a la insulina y menor inflamaci\u00f3n hep\u00e1tica, incluso en roedores sometidos a dietas hipercal\u00f3ricas.<\/p>\n

La neuritina 1 se hab\u00eda descrito previamente como un factor implicado en la plasticidad neuronal. El estudio demuestra ahora que tambi\u00e9n se produce y act\u00faa en el tejido adiposo marr\u00f3n, un tipo de grasa especializada en generar calor mediante la termog\u00e9nesis, que consiste en la quema de energ\u00eda para mantener la temperatura corporal, especialmente en condiciones de fr\u00edo. En este contexto, la prote\u00edna potencia la actividad mitocondrial y estimula la expresi\u00f3n de genes termog\u00e9nicos.<\/p>\n

<\/a><\/p>\n

Sin necesidad de comer menos<\/h2>\n

Para inducir su producci\u00f3n, el equipo utiliz\u00f3 un vector viral que dirige la sobreexpresi\u00f3n de neuritina 1 \u00fanicamente en adipocitos termog\u00e9nicos. El resultado fue una activaci\u00f3n sostenida del metabolismo sin reducci\u00f3n de la ingesta ni cambios en la actividad f\u00edsica de los animales.<\/p>\n

\u201cEl hallazgo sugiere que esta prote\u00edna podr\u00eda tener un gran valor terap\u00e9utico para tratar la obesidad y sus comorbilidades, como la diabetes tipo 2 o el h\u00edgado graso, mediante un mecanismo completamente distinto a los actuales\u201d, destaca la Dra. S\u00e1nchez-Feutrie.<\/p>\n

<\/a><\/p>\n

Implicaciones en salud humana<\/h2>\n

Adem\u00e1s de los resultados en modelos animales, datos gen\u00e9ticos humanos muestran que la neuritina 1 se relaciona con la predisposici\u00f3n a la obesidad. Este hallazgo refuerza su relevancia m\u00e1s all\u00e1 del laboratorio. El equipo trabaja en el desarrollo de una posible terapia basada en esta v\u00eda.<\/p>\n

El equipo trabaja ya en el desarrollo de una posible terapia basada en esta v\u00eda<\/p>\n

El estudio ha contado con la colaboraci\u00f3n de varias plataformas cient\u00edficas del IRB Barcelona \u2014Bioinform\u00e1tica y Bioestad\u00edstica, Gen\u00f3mica Funcional, Expresi\u00f3n de prote\u00ednas e Histopatolog\u00eda\u2014, as\u00ed como de investigadores de instituciones internacionales como el CNRS (Francia), el Karolinska Institutet (Suecia) y la Universidad de Houston (EE UU).<\/p>\n

Referencia:<\/p>\n

Manuela S\u00e1nchez-Feutrie et al. \u201cIdentification of Neuritin 1 as a local metabolic regulator of brown adipose tissue\u201d,. Nature Communications<\/a>\u00a0(2025)<\/p>","protected":false},"excerpt":{"rendered":"

\u00bfEs posible tratar la obesidad sin reducir la ingesta alimentaria? Un nuevo estudio del Instituto de Investigaci\u00f3n Biom\u00e9dica (IRB Barcelona) apunta que, al menos en modelos de rat\u00f3n, s\u00ed lo es. El trabajo, publicado en la revista Nature Communications y liderado\u00a0por Antonio Zorzano\u00a0y\u00a0Manuela S\u00e1nchez-Feutrie, del IRB, revela que la\u00a0neuritina 1, una prote\u00edna hasta ahora vinculada […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-180592","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nLa activaci\u00f3n del tejido adiposo marr\u00f3n mediante la prote\u00edna neuritina 1 protege frente a la obesidad - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/la-activacion-del-tejido-adiposo-marron-mediante-la-proteina-neuritina-1-protege-frente-a-la-obesidad\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La activaci\u00f3n del tejido adiposo marr\u00f3n mediante la prote\u00edna neuritina 1 protege frente a la obesidad\" \/>\n<meta property=\"og:description\" content=\"\u00bfEs posible tratar la obesidad sin reducir la ingesta alimentaria? 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