{"id":182306,"date":"2025-09-24T09:28:15","date_gmt":"2025-09-24T08:28:15","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/desarrollan-una-terapia-genica-contra-el-sarcoma-de-ewing-un-tipo-de-cancer-infantil\/"},"modified":"2025-09-24T09:28:15","modified_gmt":"2025-09-24T08:28:15","slug":"desarrollan-una-terapia-genica-contra-el-sarcoma-de-ewing-un-tipo-de-cancer-infantil","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/desarrollan-una-terapia-genica-contra-el-sarcoma-de-ewing-un-tipo-de-cancer-infantil\/","title":{"rendered":"Desarrollan una terapia g\u00e9nica contra el sarcoma de Ewing, un tipo de c\u00e1ncer infantil"},"content":{"rendered":"

Un estudio publicado en la revista Scientific Reports<\/a> por un equipo del Instituto de Salud Carlos III (ISCIII) ha demostrado en estudios precl\u00ednicos que es posible destruir las c\u00e9lulas tumorales del sarcoma de Ewing mediante el empleo de una estrategia basada en genes \u2018suicidas\u2019. Esta denominaci\u00f3n se refiere al uso de un gen cuya expresi\u00f3n provoca el \u2018suicidio\u2019 de las propias c\u00e9lulas que lo expresan, favoreciendo la eliminaci\u00f3n de c\u00e9lulas tumorales.<\/p>\n

Cada a\u00f1o se diagnostican en Espa\u00f1a\u00a025 nuevos casos de sarcoma de Ewing, que afecta a ni\u00f1os y adolescentes<\/p>\n

El sarcoma de Ewing es un tipo de c\u00e1ncer infantil que\u00a0afecta a los huesos y los tejidos blandos y para el que ha habido pocos avances terap\u00e9uticos en los \u00faltimos a\u00f1os. Se trata de un tumor maligno que afecta a ni\u00f1os y adolescentes y del que se diagnostica cada a\u00f1o en Espa\u00f1a aproximadamente 25 nuevos casos, por lo que esta enfermedad se considera tambi\u00e9n, como la mayor\u00eda de los tumores infantiles, una enfermedad rara.<\/p>\n

Aunque actualmente se consiguen tasas de supervivencia de aproximadamente el 70 %, desde hace a\u00f1os no se vislumbran avances significativos en los tratamientos, por lo que es necesario avanzar en terapias innovadoras que tengan menos efectos secundarios que los tratamientos actuales (radioterapia y quimioterapia), y que permitan mejorar las tasas de supervivencia, especialmente en los pacientes con met\u00e1stasis y reca\u00eddas, que tienen mucho peor pron\u00f3stico.<\/p>\n

<\/a><\/p>\n

Una estrategia espec\u00edfica contra c\u00e9lulas tumorales<\/h2>\n

Los investigadores han utilizado para el estudio un adenovirus, un virus frecuentemente utilizado en terapia g\u00e9nica contra el c\u00e1ncer, para introducir en las c\u00e9lulas de sarcoma de Ewing un gen \u2018suicida\u2019 derivado del virus del herpes simplex (HSV-TK). Cuando las c\u00e9lulas de sarcoma de Ewing son infectadas por el adenovirus terap\u00e9utico, estas expresan el gen \u2018suicida\u2019 HSV-TK.<\/p>\n

El pa\u00eds de residencia puede influir en la detecci\u00f3n temprana del c\u00e1ncer infantil<\/a><\/p>\n

Nuevos mecanismos que aumentan la agresividad del c\u00e1ncer pedi\u00e1trico sarcoma de Ewing<\/a><\/p>\n

Un beb\u00e9 con una enfermedad rara, primer paciente tratado mediante terapia g\u00e9nica<\/a><\/p>\n

Este gen es inocuo, pero cuando se combina con el compuesto ganciclovir \u2014un f\u00e1rmaco com\u00fanmente utilizado para combatir las infecciones con los virus del herpes \u2014, es capaz de transformarlo en un compuesto t\u00f3xico que provoca la muerte, en este caso, de las c\u00e9lulas de sarcoma de Ewing.<\/p>\n

Una de las ventajas de la terapia desarrollada por este grupo es que el gen \u2018suicida\u2019 s\u00f3lo se expresa en las c\u00e9lulas de sarcoma de Ewing, otorg\u00e1ndole al sistema una gran especificidad y, por tanto, reduciendo la probabilidad de efectos secundarios de la terapia.\u00a0<\/p>\n

<\/a><\/p>\n

Reducci\u00f3n del tama\u00f1o del tumor<\/h2>\n

Esta estrategia ha sido previamente utilizada por el mismo grupo del ISCIII para expresar de manera espec\u00edfica el sistema CRISPR\/Cas9 en c\u00e9lulas de sarcoma de Ewing<\/a>. Sin embargo, mientras que con la tecnolog\u00eda CRISPR\/Cas9 fue posible ralentizar el crecimiento tumoral, con esta nueva aproximaci\u00f3n los investigadores han conseguido reducir el tama\u00f1o del tumor, y en algunos casos su completa eliminaci\u00f3n en modelos precl\u00ednicos, lo que indica que esta nueva terapia con genes suicidas podr\u00eda ser potencialmente curativa.<\/p>\n

<\/p>\n

En los \u00faltimos 20 a\u00f1os no ha habido ning\u00fan avance significativo en los tratamientos para este c\u00e1ncer infantil. Es absolutamente imprescindible explorar nuevas v\u00edas de tratamiento<\/p>\n

Javier Alonso, ISCIII
\n<\/p>\n

En palabras del director de la investigaci\u00f3n, Javier Alonso, en los \u00faltimos 20 a\u00f1os \u201cno ha habido ning\u00fan avance significativo en los tratamientos para este c\u00e1ncer infantil devastador. Es, por tanto, absolutamente imprescindible explorar nuevas v\u00edas de tratamiento que sean diferentes a los tratamientos convencionales, que sabemos ya han llegado al m\u00e1ximo que pueden dar\u201d.<\/p>\n

La nueva terapia ha demostrado ser muy espec\u00edfica y muy eficaz en los estudios precl\u00ednicos, \u201cpor lo que creemos que esta terapia podr\u00eda probarse en un primer ensayo cl\u00ednico en pacientes en un plazo relativamente corto de tiempo, si disponemos de la financiaci\u00f3n adecuada\u201d, concluye Alonso.<\/p>\n

Referencia:<\/p>\n

Cervera ST, Alonso J. Suicide gene therapy targeting ewing sarcoma via an ewing-specific GGAA promoter.\u00a0Scientific Reports<\/a>\u00a0(2025).<\/p>","protected":false},"excerpt":{"rendered":"

Un estudio publicado en la revista Scientific Reports por un equipo del Instituto de Salud Carlos III (ISCIII) ha demostrado en estudios precl\u00ednicos que es posible destruir las c\u00e9lulas tumorales del sarcoma de Ewing mediante el empleo de una estrategia basada en genes \u2018suicidas\u2019. Esta denominaci\u00f3n se refiere al uso de un gen cuya expresi\u00f3n […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-182306","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nDesarrollan una terapia g\u00e9nica contra el sarcoma de Ewing, un tipo de c\u00e1ncer infantil - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/desarrollan-una-terapia-genica-contra-el-sarcoma-de-ewing-un-tipo-de-cancer-infantil\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desarrollan una terapia g\u00e9nica contra el sarcoma de Ewing, un tipo de c\u00e1ncer infantil\" \/>\n<meta property=\"og:description\" content=\"Un estudio publicado en la revista Scientific Reports por un equipo del Instituto de Salud Carlos III (ISCIII) ha demostrado en estudios precl\u00ednicos que es posible destruir las c\u00e9lulas tumorales del sarcoma de Ewing mediante el empleo de una estrategia basada en genes \u2018suicidas\u2019. 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