{"id":183509,"date":"2025-10-06T11:31:26","date_gmt":"2025-10-06T10:31:26","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/brunkow-ramsdell-y-sakaguchi-ganan-el-nobel-de-medicina-2025-por-sus-hallazgos-sobre-el-sistema-inmunitario\/"},"modified":"2025-10-06T11:31:26","modified_gmt":"2025-10-06T10:31:26","slug":"brunkow-ramsdell-y-sakaguchi-ganan-el-nobel-de-medicina-2025-por-sus-hallazgos-sobre-el-sistema-inmunitario","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/brunkow-ramsdell-y-sakaguchi-ganan-el-nobel-de-medicina-2025-por-sus-hallazgos-sobre-el-sistema-inmunitario\/","title":{"rendered":"Brunkow, Ramsdell y Sakaguchi ganan el Nobel de Medicina 2025 por sus hallazgos sobre el sistema inmunitario"},"content":{"rendered":"<p>La Asamblea Nobel del Instituto Karolinska ha concedido el <a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/press-release\/\" target=\"_blank\">Premio Nobel de Fisiolog\u00eda o Medicina 2025<\/a> a Mary E. Brunkow (Institute for Systems Biology, Seattle, EE UU), Fred Ramsdell (Sonoma Biotherapeutics, San Francisco, EE UU) y Shimon Sakaguchi (Universidad de Osaka, Jap\u00f3n), \u201cpor sus descubrimientos sobre la tolerancia inmunitaria perif\u00e9rica\u201d.<\/p>\n<p>El sistema inmunitario es una herramienta poderosa que nos protege frente a miles de microorganismos diferentes cada d\u00eda. Pero debe mantenerse bajo control: si sus mecanismos de defensa se desregulan, puede atacar los propios \u00f3rganos y tejidos del cuerpo.<\/p>\n<p>Los tres galardonados han sido reconocidos por identificar c\u00f3mo se regula este equilibrio. Sus descubrimientos revelaron la existencia de las c\u00e9lulas T reguladoras, las \u201cguardianas\u201d del sistema inmunitario, que impiden que nuestras propias defensas se vuelvan contra nosotros.<\/p>\n<p>\u201cSus descubrimientos han sido decisivos para comprender c\u00f3mo funciona el sistema inmunitario y por qu\u00e9 no todos desarrollamos graves enfermedades autoinmunes\u201d, se\u00f1al\u00f3 Olle K\u00e4mpe, presidente del Comit\u00e9 Nobel.<\/p>\n<p><a><\/a><\/p>\n<h2>Los descubrimientos premiados<\/h2>\n<p>En 1995, el inmun\u00f3logo japon\u00e9s Shimon Sakaguchi (nacido en 1951, doctor en Medicina y en Filosof\u00eda por la Universidad de Kioto) desafi\u00f3 la idea dominante de que la tolerancia inmunitaria solo se deb\u00eda a la eliminaci\u00f3n de c\u00e9lulas peligrosas en el timo \u2014un proceso conocido como tolerancia central\u2014. Descubri\u00f3 una nueva clase de c\u00e9lulas inmunitarias, las c\u00e9lulas T reguladoras, que protegen al organismo de las enfermedades autoinmunes.<\/p>\n<p>A\u00f1os despu\u00e9s, en 2001, los investigadores estadounidenses Mary E. Brunkow (nacida en 1961, doctora por la Universidad de Princeton) y Fred Ramsdell (nacido en 1960, doctor por la Universidad de California en Los \u00c1ngeles) realizaron el segundo hallazgo clave. Estudiando una cepa de ratones especialmente vulnerable a enfermedades autoinmunes, identificaron una mutaci\u00f3n en el gen Foxp3, y demostraron que alteraciones en su equivalente humano causan una enfermedad autoinmune grave llamada IPEX.<\/p>\n<p>En 2003, Sakaguchi uni\u00f3 ambas l\u00edneas de investigaci\u00f3n al demostrar que el gen Foxp3 controla el desarrollo de las c\u00e9lulas T reguladoras. Estas c\u00e9lulas vigilan la actividad del sistema inmunitario y garantizan que el organismo tolere sus propios tejidos.<\/p>\n<p><a><\/a><\/p>\n<h2>Un campo que transform\u00f3 la inmunolog\u00eda<\/h2>\n<p>Los descubrimientos de Brunkow, Ramsdell y Sakaguchi dieron origen al campo de la tolerancia perif\u00e9rica, que abri\u00f3 nuevas v\u00edas terap\u00e9uticas para tratar el c\u00e1ncer, las enfermedades autoinmunes y mejorar los trasplantes de \u00f3rganos. Varias de las terapias inspiradas en este mecanismo se encuentran actualmente en ensayos cl\u00ednicos.<\/p>\n<p>El premio, dotado con 11 millones de coronas suecas, ser\u00e1 compartido a partes iguales entre los tres galardonados.<\/p>\n<p>\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>La Asamblea Nobel del Instituto Karolinska ha concedido el Premio Nobel de Fisiolog\u00eda o Medicina 2025 a Mary E. Brunkow (Institute for Systems Biology, Seattle, EE UU), Fred Ramsdell (Sonoma Biotherapeutics, San Francisco, EE UU) y Shimon Sakaguchi (Universidad de Osaka, Jap\u00f3n), \u201cpor sus descubrimientos sobre la tolerancia inmunitaria perif\u00e9rica\u201d. El sistema inmunitario es una [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-183509","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.9 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Brunkow, Ramsdell y Sakaguchi ganan el Nobel de Medicina 2025 por sus hallazgos sobre el sistema inmunitario - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/brunkow-ramsdell-y-sakaguchi-ganan-el-nobel-de-medicina-2025-por-sus-hallazgos-sobre-el-sistema-inmunitario\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brunkow, Ramsdell y Sakaguchi ganan el Nobel de Medicina 2025 por sus hallazgos sobre el sistema inmunitario\" \/>\n<meta property=\"og:description\" content=\"La Asamblea Nobel del Instituto Karolinska ha concedido el Premio Nobel de Fisiolog\u00eda o Medicina 2025 a Mary E. 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