{"id":188654,"date":"2025-11-21T12:28:20","date_gmt":"2025-11-21T11:28:20","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/identifican-la-celula-que-provoca-el-tumor-pediatrico-del-sarcoma-de-ewing\/"},"modified":"2025-11-21T12:28:20","modified_gmt":"2025-11-21T11:28:20","slug":"identifican-la-celula-que-provoca-el-tumor-pediatrico-del-sarcoma-de-ewing","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/identifican-la-celula-que-provoca-el-tumor-pediatrico-del-sarcoma-de-ewing\/","title":{"rendered":"Identifican la c\u00e9lula que provoca el tumor pedi\u00e1trico del Sarcoma de Ewing"},"content":{"rendered":"

Un grupo de investigadores ha identificado la c\u00e9lula que est\u00e1 en el origen del Sarcoma de Ewing, un tumor pedi\u00e1trico de gran agresividad. Son los resultados del trabajo de un equipo multic\u00e9ntrico que ha liderado el Instituto de Investigaci\u00f3n del Hospital del Mar y el Instituto de Investigaci\u00f3n Sant Joan de D\u00e9u, ambos de Barcelona, y que publica la revista Nature Communications<\/a>.<\/p>\n

El sarcoma de Ewing es un tipo de tumor que se forma a partir de cierta clase de c\u00e9lula en el hueso o el tejido blando<\/p>\n

El sarcoma de Ewing es un tipo de tumor que se forma a partir de cierta clase de c\u00e9lula en el hueso o el tejido blando. Una de las principales caracter\u00edsticas del Sarcoma de Ewing es que, a diferencia de la mayor parte de los tumores, se produce por un \u00fanico oncog\u00e9n y de forma precoz durante el desarrollo fetal.<\/p>\n

En este proceso, dos genes se combinan para generar uno nuevo y adquieren nuevas funciones que le confieren la capacidad de desarrollar la enfermedad cuando se expresa en las c\u00e9lulas madre embrionarias mesenquim\u00e1ticas, como ha demostrado el nuevo estudio.<\/p>\n

Se trata de las c\u00e9lulas que forman la mes\u00e9nquima, el tejido embrionario del cual derivan, entre otros, el tejido muscular y conectivo del cuerpo, los vasos sangu\u00edneos y linf\u00e1ticos.<\/p>\n


\n \"Desarrollan
\n <\/a><\/p>\n

<\/a><\/p>\n

Desarrollan una terapia g\u00e9nica contra el sarcoma de Ewing, un tipo de c\u00e1ncer infantil<\/h3>\n

<\/p>\n


\n SINC
\n <\/a> <\/p>\n

<\/a><\/p>\n

C\u00e9lulas embrionarias<\/h2>\n

El estudio que ahora se publica ha conseguido, por primera vez, reproducir este mecanismo. En colaboraci\u00f3n con el laboratorio del Centro de Medicina Regenerativa de Barcelona, se han generado y purificado c\u00e9lulas mesenquim\u00e1ticas embrionarias humanas a las cuales se ha introducido el oncog\u00e9n que origina el Sarcoma de Ewing.<\/p>\n

Aunque la tasa de curaci\u00f3n de esta enfermedad se mueve entre el el 70 % de los casos, la toxicidad de los tratamientos quimioter\u00e1picos actuales deriva en efectos secundarios en los ni\u00f1os<\/p>\n

Aunque estas c\u00e9lulas no presentan caracter\u00edsticas tumorales in vitro, cuando se inoculan en ratones generan tumores similares al sarcoma de Ewing humano, manteniendo los patrones celulares y transcripcionales propios del sarcoma.<\/p>\n

Aunque la tasa de curaci\u00f3n de esta enfermedad se mueve entre el 60 y el 70 % de los casos, la toxicidad de los tratamientos quimioter\u00e1picos actuales deriva en efectos secundarios en los ni\u00f1os.<\/p>\n

As\u00ed, saber d\u00f3nde se origina la enfermedad, la c\u00e9lula que es el punto original, puede permitir abordajes m\u00e1s dirigidos y precisos, seg\u00fan la doctora Inmaculada Hern\u00e1ndez-Mu\u00f1oz, investigadora del Grupo de Investigaci\u00f3n en Enfermedades inflamatorias y neopl\u00e1sicas dermatol\u00f3gicas del Hospital del Mar Research Institute.<\/p>\n

\u201cAhora que tenemos identificada la c\u00e9lula que origina el tumor, el siguiente paso es determinar qu\u00e9 factores hacen que una c\u00e9lula que, en principio, no tiene ninguna ventaja de crecimiento, adquiera este rasgo\u201d, ha a\u00f1adido.<\/p>\n

Hern\u00e1ndez-Mu\u00f1oz I, Cuervas I et al. FLI1 expression in human embryonic mesenchymal stem cells leads to transcriptional reprograming, defective DNA damage repair and Ewing sarcoma. Nature Communications<\/a> (2025).<\/p>","protected":false},"excerpt":{"rendered":"

Un grupo de investigadores ha identificado la c\u00e9lula que est\u00e1 en el origen del Sarcoma de Ewing, un tumor pedi\u00e1trico de gran agresividad. Son los resultados del trabajo de un equipo multic\u00e9ntrico que ha liderado el Instituto de Investigaci\u00f3n del Hospital del Mar y el Instituto de Investigaci\u00f3n Sant Joan de D\u00e9u, ambos de Barcelona, […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-188654","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nIdentifican la c\u00e9lula que provoca el tumor pedi\u00e1trico del Sarcoma de Ewing - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/identifican-la-celula-que-provoca-el-tumor-pediatrico-del-sarcoma-de-ewing\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifican la c\u00e9lula que provoca el tumor pedi\u00e1trico del Sarcoma de Ewing\" \/>\n<meta property=\"og:description\" content=\"Un grupo de investigadores ha identificado la c\u00e9lula que est\u00e1 en el origen del Sarcoma de Ewing, un tumor pedi\u00e1trico de gran agresividad. 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