{"id":189524,"date":"2025-12-02T08:28:17","date_gmt":"2025-12-02T07:28:17","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\/"},"modified":"2025-12-02T08:28:17","modified_gmt":"2025-12-02T07:28:17","slug":"descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\/","title":{"rendered":"Descubren un mecanismo clave que impulsa la met\u00e1stasis en el c\u00e1ncer"},"content":{"rendered":"

Un equipo del Centro de Investigaci\u00f3n del C\u00e1ncer (Universidad de Salamanca-CSIC-FICUS) ha identificado un nuevo regulador cr\u00edtico en la progresi\u00f3n metast\u00e1sica del c\u00e1ncer.\u00a0 El avance, publicado recientemente en la revista Cancer Research<\/a>, aporta una comprensi\u00f3n m\u00e1s profunda de las modificaciones del ADN y del ARN en el c\u00e1ncer metast\u00e1sico. Los resultados permitir\u00e1n futuras terapias dirigidas que puedan mejorar los resultados cl\u00ednicos en pacientes con c\u00e1ncer de pr\u00f3stata avanzado.<\/p>\n

La prote\u00edna ZC3H13 forma parte de un complejo de las c\u00e9lulas cancerosas que se encarga de a\u00f1adir peque\u00f1as marcas qu\u00edmicas sobre el ARN mensajero<\/p>\n

En concreto, en esta investigaci\u00f3n demostr\u00f3 que la prote\u00edna ZC3H13 forma parte de un complejo de las c\u00e9lulas cancerosas que se encarga de a\u00f1adir peque\u00f1as marcas qu\u00edmicas sobre el ARN mensajero (que lleva instrucciones copiadas del ADN para fabricar prote\u00ednas). Cuando ZC3H13 se pierde, esta marca (llamada metilaci\u00f3n m6A) disminuye en ciertos ARN mensajeros.<\/p>\n

Como resultado, esos mensajes se vuelven m\u00e1s estables y por tanto se expresan m\u00e1s en estas c\u00e9lulas. Entre esos mensajeros se ha identificado el que da lugar a la prote\u00edna MYB, la cual promueve la movilidad de las c\u00e9lulas cancerosas que acaban infiltr\u00e1ndose m\u00e1s en otros tejidos, es decir, metastatizan mucho m\u00e1s.<\/p>\n

Por tanto, la ausencia de ZC3H13 disminuye la metilaci\u00f3n m6A en ARN mensajeros y favorece que las c\u00e9lulas tumorales tengan m\u00e1s facilidad para invadir y migrar, lo que ayuda a la formaci\u00f3n de met\u00e1stasis.<\/p>\n


\n \"Los
\n <\/a><\/p>\n

<\/a><\/p>\n

Los virus respiratorios \u2018despiertan\u2019 c\u00e9lulas metast\u00e1sicas de c\u00e1ncer de mama en los pulmones<\/h3>\n

<\/p>\n


\n Ana Hernando
\n <\/a> <\/p>\n

<\/a><\/p>\n

P\u00e9rdida de genes supresores de tumores<\/h2>\n

En muestras de pacientes con c\u00e1ncer de pr\u00f3stata avanzado y otros tipos como vejiga, \u00fatero, cervix y hepatocarcinoma, se ha observado que la p\u00e9rdida de la prote\u00edna ZC3H13 suele presentarse junto con la p\u00e9rdida de otros genes supresores de tumores importantes, como RB1 y BRCA2. Esta combinaci\u00f3n est\u00e1 relacionada con un pron\u00f3stico cl\u00ednico m\u00e1s desfavorable.<\/p>\n

El an\u00e1lisis del gen ZC3H13 se ha realizado con muestras de pacientes con c\u00e1ncer de pr\u00f3stata avanzado<\/p>\n

El equipo ha investigado c\u00f3mo reducir significativamente el potencial metast\u00e1sico en c\u00e9lulas deficientes en ZC3H13. Para ello, ha trabajo con modelos celulares y en modelos animales que permit\u00edan restaurar la funci\u00f3n de ZC3H13 o aumentar la metilaci\u00f3n m6A.<\/p>\n

Espec\u00edficamente, han probado como posible estrategia terap\u00e9utica para reducir la formaci\u00f3n de met\u00e1stasis inhibidores ya aprobados por la FDA (el organismo encargado de regular y aprobar medicamentos y otros productos sanitarios en Estados Unidos) que bloquean enzimas que eliminan la metilaci\u00f3n m6A. De esta forma, se contrarresta la p\u00e9rdida que ya ocurre en las c\u00e9lulas deficientes en ZC3H13.<\/p>\n

El an\u00e1lisis del gen ZC3H13 se ha realizado con muestras de pacientes con c\u00e1ncer de pr\u00f3stata avanzado. Adem\u00e1s, mediante esta investigaci\u00f3n se ha validado la mutaci\u00f3n de ZC3H13 en c\u00e1ncer de vejiga, en c\u00e1ncer escamoso de c\u00e9rvix, en hepatocarcinoma y en c\u00e1ncer de \u00fatero. Esta validaci\u00f3n puede abrir la posibilidad de extender la relevancia cl\u00ednica de estos resultados a dichos tumores.<\/p>\n

Este trabajo ha sido posible gracias a la financiaci\u00f3n proporcionada por el Ministerio de Ciencia e Innovaci\u00f3n de Espa\u00f1a, la Fundaci\u00f3n Cient\u00edfica AECC, la Universidad de Salamanca, la Fundaci\u00f3n Memoria de Samuel Sol\u00f3rzano Barruso, y programas de apoyo a la investigaci\u00f3n como los planes estrat\u00e9gicos de Castilla y Le\u00f3n con fondos europeos, adem\u00e1s de becas para formaci\u00f3n y movilidad otorgadas por la Junta de Castilla y Le\u00f3n y el Ministerio de Ciencia, Innovaci\u00f3n y Universidades.<\/p>\n

Referencia:<\/p>\n

Monteagudo-Garc\u00eda, Blanco, S et al. ZC3H13 Loss Drives Cancer Metastatic Progression by Disrupting m6A RNA Methylation. Cancer Research<\/a> (2025).<\/p>","protected":false},"excerpt":{"rendered":"

Un equipo del Centro de Investigaci\u00f3n del C\u00e1ncer (Universidad de Salamanca-CSIC-FICUS) ha identificado un nuevo regulador cr\u00edtico en la progresi\u00f3n metast\u00e1sica del c\u00e1ncer.\u00a0 El avance, publicado recientemente en la revista Cancer Research, aporta una comprensi\u00f3n m\u00e1s profunda de las modificaciones del ADN y del ARN en el c\u00e1ncer metast\u00e1sico. Los resultados permitir\u00e1n futuras terapias dirigidas […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-189524","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nDescubren un mecanismo clave que impulsa la met\u00e1stasis en el c\u00e1ncer - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Descubren un mecanismo clave que impulsa la met\u00e1stasis en el c\u00e1ncer\" \/>\n<meta property=\"og:description\" content=\"Un equipo del Centro de Investigaci\u00f3n del C\u00e1ncer (Universidad de Salamanca-CSIC-FICUS) ha identificado un nuevo regulador cr\u00edtico en la progresi\u00f3n metast\u00e1sica del c\u00e1ncer.\u00a0 El avance, publicado recientemente en la revista Cancer Research, aporta una comprensi\u00f3n m\u00e1s profunda de las modificaciones del ADN y del ARN en el c\u00e1ncer metast\u00e1sico. Los resultados permitir\u00e1n futuras terapias dirigidas […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/helloproject.es\/vigilancia\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"bip4ex\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-02T07:28:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cdn.agenciasinc.es\/var\/ezwebin_site\/storage\/images\/noticias\/los-virus-respiratorios-despiertan-celulas-metastasicas-de-cancer-de-mama-en-los-pulmones\/12332103-1-esl-MX\/Los-virus-respiratorios-despiertan-celulas-metastasicas-de-cancer-de-mama-en-los-pulmones.jpg\" \/>\n<meta name=\"author\" content=\"Luis Miguel Mej\u00edas Ramos\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Luis Miguel Mej\u00edas Ramos\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\\\/\"},\"author\":{\"name\":\"Luis Miguel Mej\u00edas Ramos\",\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/#\\\/schema\\\/person\\\/3767b0619d59a11570372c821f8619ca\"},\"headline\":\"Descubren un mecanismo clave que impulsa la met\u00e1stasis en el c\u00e1ncer\",\"datePublished\":\"2025-12-02T07:28:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\\\/\"},\"wordCount\":702,\"publisher\":{\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cdn.agenciasinc.es\\\/var\\\/ezwebin_site\\\/storage\\\/images\\\/noticias\\\/los-virus-respiratorios-despiertan-celulas-metastasicas-de-cancer-de-mama-en-los-pulmones\\\/12332103-1-esl-MX\\\/Los-virus-respiratorios-despiertan-celulas-metastasicas-de-cancer-de-mama-en-los-pulmones.jpg\",\"articleSection\":[\"Noticias\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\\\/\",\"url\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/descubren-un-mecanismo-clave-que-impulsa-la-metastasis-en-el-cancer\\\/\",\"name\":\"Descubren un mecanismo clave que impulsa la met\u00e1stasis en el c\u00e1ncer - 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