{"id":195369,"date":"2026-01-22T16:28:09","date_gmt":"2026-01-22T15:28:09","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/"},"modified":"2026-01-22T16:28:09","modified_gmt":"2026-01-22T15:28:09","slug":"tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/","title":{"rendered":"Tomar omeprazol no se asocia a un mayor riesgo de c\u00e1ncer de est\u00f3mago"},"content":{"rendered":"

El c\u00e1ncer de est\u00f3mago es la quinta neoplasia maligna m\u00e1s com\u00fan en todo el mundo, y desde 1980 se ha relacionado el consumo de\u00a0medicamentos\u00a0contra el reflujo g\u00e1strico con la posibilidad de desarrollar este tipo de enfermedad tumoral.\u00a0<\/p>\n

Un reciente estudio publicado en\u00a0The British Medical Journal\u00a0desmiente que una ingesta frecuente pueda degenerar en un mayor riesgo de padecer adenocarcinoma g\u00e1strico, la forma m\u00e1s frecuente de este tipo c\u00e1ncer.\u00a0<\/p>\n

Las investigaciones previas estaban limitadas por el\u00a0bajo valor estad\u00edstico, un\u00a0seguimiento incompleto y\u00a0la exposici\u00f3n del omeprazol poco antes de que se diagnosticara el carcinoma<\/p>\n

Las observaciones previas apuntaban a que estos inhibidores induc\u00edan una producci\u00f3n elevada de\u00a0gastrina\u00a0\u2013una hormona que regula la secreci\u00f3n de \u00e1cidos estomacales\u2013 y la proliferaci\u00f3n resultante de p\u00f3lipos g\u00e1stricos potencialmente malignos.\u00a0<\/p>\n

Sin embargo, aquellas investigaciones se vieron obstaculizadas por\u00a0limitaciones metodol\u00f3gicas, como el bajo valor estad\u00edstico, un\u00a0seguimiento incompleto, la exposici\u00f3n del omeprazol poco antes de que se diagnosticara el carcinoma y otros puntos de confusi\u00f3n relevantes.\u00a0<\/p>\n


\n \"La
\n <\/a><\/p>\n

<\/a><\/p>\n

La \u2018Helicobacter pylori\u2019 podr\u00eda causar casi 12 millones de casos de c\u00e1ncer de est\u00f3mago<\/h3>\n

<\/p>\n


\n Carmen de Ram\u00f3n
\n <\/a> <\/p>\n

<\/a><\/p>\n

Investigaci\u00f3n multinacional<\/h2>\n

Los investigadores de este nuevo estudio basaron sus hallazgos en la poblaci\u00f3n y utilizaron datos procedentes de\u00a0Dinamarca, Finlandia, Islandia, Noruega y Suecia\u00a0entre 1994 y el a\u00f1o 2000.\u00a0<\/p>\n

Emplearon registros diferentes en cada uno de estos pa\u00edses: informaci\u00f3n sobre la\u00a0poblaci\u00f3n total, los medicamentos recetados, los casos de c\u00e1ncer, los diagn\u00f3sticos realizados y causas de muerte.\u00a0<\/p>\n

No encontraron una asociaci\u00f3n directa entre el uso de este inhibidor y el desarrollo de c\u00e1ncer de est\u00f3mago entre los participantes.<\/p>\n

El estudio incluy\u00f3 17 232 casos de adenocarcinoma g\u00e1strico (no cardiaco) y 72 297\u00a0controles. Adem\u00e1s, la exposici\u00f3n al\u00a0inhibidor de la bomba de protones\u00a0fue superior a un 1 a\u00f1o y excluyeron los 12 meses anteriores a la fecha del diagn\u00f3stico o la fecha de inclusi\u00f3n.\u00a0El uso a largo plazo de omeprazol y derivados se observ\u00f3 en el 10,2 % de los casos y en el 9,5 % controles.\u00a0<\/p>\n

El resultado fue que no encontraron una asociaci\u00f3n directa entre el uso de este inhibidor y el desarrollo de c\u00e1ncer de est\u00f3mago entre los participantes. El riesgo fue parecido para el uso de antagonistas del receptor de histamina-2.<\/p>\n


\n \"H\u00e1bitos
\n <\/a><\/p>\n

<\/a><\/p>\n

H\u00e1bitos diet\u00e9ticos saludables contra el c\u00e1ncer g\u00e1strico<\/h3>\n

<\/p>\n

SINC<\/p>\n

<\/a><\/p>\n

Uno de los f\u00e1rmacos m\u00e1s prescritos en Espa\u00f1a<\/h2>\n

Los autores del proyecto identificaron m\u00faltiples fuentes de error que condujeron a una asociaci\u00f3n falsa entre estos medicamentos y el c\u00e1ncer g\u00e1strico.\u00a0<\/p>\n

Entre ellos, observaron la inclusi\u00f3n del uso de inhibidores de la bomba de protones poco antes del diagn\u00f3stico de adenocarcinoma g\u00e1strico, el uso a corto plazo de omeprazol y la falta de ajuste de variables relacionadas como el\u00a0Helicobacter pylori<\/p>\n

El experto a\u00f1ade que se trata de un estudio observacional, por lo que no se puede establecer una relaci\u00f3n de causa y efecto definitiva<\/p>\n

Seg\u00fan expone al SMC Espa\u00f1a el gastroenter\u00f3logo del Hospital Universitario de Galdakao (Bizkaia),\u00a0Iago Rodr\u00edguez- Lago, los resultados aclaran esta situaci\u00f3n al demostrar que, una vez que se ajustan factores determinantes como la infecci\u00f3n por la bacteria\u00a0Helicobacter pylori, el tabaquismo, la obesidad y la diabetes, la supuesta asociaci\u00f3n desaparece.\u00a0<\/p>\n

\u201cTanto para todo el personal sanitario como pacientes, este hallazgo es de gran valor e inter\u00e9s, ya que aporta tranquilidad y reafirma la seguridad de los inhibidores de la bomba de protones a largo plazo, unos de los f\u00e1rmacos m\u00e1s prescritos en Espa\u00f1a\u201d, expone.<\/p>\n

Pese a ello , el experto a\u00f1ade que se trata de un estudio observacional, por lo que no se puede establecer una relaci\u00f3n de causa y efecto definitiva. A su juicio, \u201cexisten factores que no pudieron ser medidos, como la dieta de los pacientes, sus antecedentes familiares de c\u00e1ncer de est\u00f3mago, o la predisposici\u00f3n variable a este tipo de tumor en ciertas \u00e1reas geogr\u00e1ficas\u201d, concluye.\u00a0\u00a0<\/p>\n

Referencia:\u00a0<\/p>\n

Lagergren, J. et al.\u00a0Long term use of proton pump inhibitors and risk of stomach cancer: population based case-control study in five Nordic countries. The British Medical Journal<\/a>. 2025<\/p>","protected":false},"excerpt":{"rendered":"

El c\u00e1ncer de est\u00f3mago es la quinta neoplasia maligna m\u00e1s com\u00fan en todo el mundo, y desde 1980 se ha relacionado el consumo de\u00a0medicamentos\u00a0contra el reflujo g\u00e1strico con la posibilidad de desarrollar este tipo de enfermedad tumoral.\u00a0 Un reciente estudio publicado en\u00a0The British Medical Journal\u00a0desmiente que una ingesta frecuente pueda degenerar en un mayor riesgo […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-195369","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nTomar omeprazol no se asocia a un mayor riesgo de c\u00e1ncer de est\u00f3mago - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tomar omeprazol no se asocia a un mayor riesgo de c\u00e1ncer de est\u00f3mago\" \/>\n<meta property=\"og:description\" content=\"El c\u00e1ncer de est\u00f3mago es la quinta neoplasia maligna m\u00e1s com\u00fan en todo el mundo, y desde 1980 se ha relacionado el consumo de\u00a0medicamentos\u00a0contra el reflujo g\u00e1strico con la posibilidad de desarrollar este tipo de enfermedad tumoral.\u00a0 Un reciente estudio publicado en\u00a0The British Medical Journal\u00a0desmiente que una ingesta frecuente pueda degenerar en un mayor riesgo […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/\" \/>\n<meta property=\"og:site_name\" content=\"bip4ex\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-22T15:28:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cdn.agenciasinc.es\/var\/ezwebin_site\/storage\/images\/noticias\/la-helicobacter-pylori-podria-causar-casi-12-millones-de-casos-de-cancer-de-estomago\/12325836-1-esl-MX\/La-Helicobacter-pylori-podria-causar-casi-12-millones-de-casos-de-cancer-de-estomago.png\" \/>\n<meta name=\"author\" content=\"Luis Miguel Mej\u00edas Ramos\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Luis Miguel Mej\u00edas Ramos\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/\"},\"author\":{\"name\":\"Luis Miguel Mej\u00edas Ramos\",\"@id\":\"https:\/\/helloproject.es\/vigilancia\/#\/schema\/person\/3767b0619d59a11570372c821f8619ca\"},\"headline\":\"Tomar omeprazol no se asocia a un mayor riesgo de c\u00e1ncer de est\u00f3mago\",\"datePublished\":\"2026-01-22T15:28:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/\"},\"wordCount\":738,\"publisher\":{\"@id\":\"https:\/\/helloproject.es\/vigilancia\/#organization\"},\"image\":{\"@id\":\"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/cdn.agenciasinc.es\/var\/ezwebin_site\/storage\/images\/noticias\/la-helicobacter-pylori-podria-causar-casi-12-millones-de-casos-de-cancer-de-estomago\/12325836-1-esl-MX\/La-Helicobacter-pylori-podria-causar-casi-12-millones-de-casos-de-cancer-de-estomago.png\",\"articleSection\":[\"Noticias\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/\",\"url\":\"https:\/\/helloproject.es\/vigilancia\/tomar-omeprazol-no-se-asocia-a-un-mayor-riesgo-de-cancer-de-estomago\/\",\"name\":\"Tomar omeprazol no se asocia a un mayor riesgo de c\u00e1ncer de est\u00f3mago - 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