{"id":198145,"date":"2026-02-11T12:28:34","date_gmt":"2026-02-11T11:28:34","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\/"},"modified":"2026-02-11T12:28:34","modified_gmt":"2026-02-11T11:28:34","slug":"las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\/","title":{"rendered":"Las c\u00e9lulas no contr\u00e1ctiles del coraz\u00f3n son responsables de la persistencia de la arritmia m\u00e1s com\u00fan"},"content":{"rendered":"

Tradicionalmente, la fibrilaci\u00f3n auricular se ha considerado un trastorno el\u00e9ctrico de las c\u00e9lulas contr\u00e1ctiles del coraz\u00f3n. Sin embargo, un trabajo del\u00a0Centro Nacional de Investigaciones Cardiovasculares Carlos III\u00a0(CNIC) revela que algunas regiones auriculares desarrollan un entorno celular caracter\u00edstico que favorece la persistencia de la arritmia.\u00a0<\/p>\n

Estas \u00e1reas se denominan\u00a0regiones impulsoras\u00a0y presentan una actividad el\u00e9ctrica m\u00e1s r\u00e1pida que el tejido circundante. Act\u00faan como \u00abverdaderos motores\u00bb que mantienen la fibrilaci\u00f3n auricular en el tiempo, seg\u00fan explican los investigadores,\u00a0<\/p>\n


\n \"Un
\n <\/a><\/p>\n

<\/a><\/p>\n

Un modelo de IA para precisar el diagn\u00f3stico y tratamiento de arritmias de coraz\u00f3n<\/h3>\n

<\/p>\n


\n SINC
\n <\/a> <\/p>\n

<\/a><\/p>\n

Funci\u00f3n protectora y de soporte metab\u00f3lico<\/h2>\n

El estudio, publicado en\u00a0Circulation Research,\u00a0identific\u00f3 diferencias significativas en la abundancia, tipo y funci\u00f3n de c\u00e9lulas \u2013fibroblastos y macr\u00f3fagos\u2013\u00a0que no participaban en la contracci\u00f3n directa del m\u00fasculo cardiaco pero que s\u00ed influ\u00edan de forma decisiva en el funcionamiento del tejido.\u00a0<\/p>\n

Seg\u00fan explica a SINC el l\u00edder de la investigaci\u00f3n y jefe del grupo de Desarrollo Avanzado en Mecanismos y Terapias de Arritmias del CNIC,\u00a0David Filgueiras Rama,\u00a0\u201cestas c\u00e9lulas participan en la generaci\u00f3n de un microambiente que favorece la supervivencia de los cardiomiocitos y les permite mantener frecuencias de activaci\u00f3n elevadas, lo que se asocia a la fibrilaci\u00f3n auricular persistente\u201d.<\/p>\n

Los expertos concluyeron que la presencia de esta combinaci\u00f3n de c\u00e9lulas ayudar\u00eda a que los cardiomiocitos\u00a0toleraran la demanda el\u00e9ctrica y energ\u00e9tica que impone la fibrilaci\u00f3n auricular<\/p>\n

El equipo de la primera autora de este trabajo,\u00a0Ana Sim\u00f3n Chica, observ\u00f3 que los macr\u00f3fagos presentes en estas regiones no mostraban el perfil inflamatorio cl\u00e1sico de la fibrilaci\u00f3n auricular.\u00a0<\/p>\n

En su lugar, observ\u00f3 que hab\u00eda mayor proporci\u00f3n de c\u00e9lulas asociadas a funciones protectoras, soporte metab\u00f3lico y supervivencia celular. Los expertos concluyeron que la presencia de esta combinaci\u00f3n de c\u00e9lulas ayudar\u00eda a los\u00a0cardiomiocitos\u00a0a tolerar la demanda el\u00e9ctrica y energ\u00e9tica que impone este tipo de condici\u00f3n.\u00a0<\/p>\n

<\/a><\/p>\n

La ablaci\u00f3n interrumpe la arritmia<\/h2>\n

Para saberlo, los investigadores analizaron el tejido card\u00edaco de pacientes con fibrilaci\u00f3n auricular persistente y estudiaron modelos experimentales avanzados con caracter\u00edsticas similares al coraz\u00f3n humano.<\/p>\n

Asimismo, demostraron la relevancia de estas regiones impulsoras al observar que su eliminaci\u00f3n selectiva, mediante t\u00e9cnicas como la ablaci\u00f3n, interrump\u00eda la arritmia y se asociaba a una mejor\u00eda en el control del ritmo a largo plazo.<\/p>\n

El estudio abre la puerta a nuevas estrategias terap\u00e9uticas dirigidas a poblaciones celulares y moleculares, m\u00e1s all\u00e1 de los cardiomiocitos<\/p>\n

\u201cEn todo caso, cabe resaltar que este sustrato puede evolucionar en el tiempo\u201d, a\u00f1ade Filgueiras. \u201cEn el tratamiento integral de estos pacientes, ser\u00e1 fundamental considerar estrategias de vida saludable y control adecuado de factores de riesgo cardiovascular\u201d, concluye.\u00a0<\/p>\n

Hoy en d\u00eda, la fibrilaci\u00f3n auricular es el trastorno el\u00e9ctrico m\u00e1s habitual y representa uno de los mayores retos terap\u00e9uticos en fases persistentes, donde la vuelta a un ritmo normal es muy poco probable.\u00a0<\/p>\n

Los autores destacan que estos hallazgos describen mecanismos adaptativos regionales y espec\u00edficos en cada paciente que permiten la persistencia de la fibrilaci\u00f3n auricular. Adem\u00e1s, refutan la idea, a\u00fan extendida, de que el remodelado auricular \u2013cambios en las aur\u00edculas producidos por la arritmia\u2013 ocurre de forma uniforme en todo el coraz\u00f3n.\u00a0<\/p>\n

El estudio abre la puerta a nuevas estrategias terap\u00e9uticas dirigidas a poblaciones celulares y moleculares, m\u00e1s all\u00e1 de los cardiomiocitos, concluyen los investigadores.\u00a0<\/p>\n

Referencia:<\/p>\n

Simon-Chica, A. et al.\u00a0Cardiac macrophages and fibroblasts modulate atrial fibrillation maintenance. Circulation Research<\/a>. 2025<\/p>","protected":false},"excerpt":{"rendered":"

Tradicionalmente, la fibrilaci\u00f3n auricular se ha considerado un trastorno el\u00e9ctrico de las c\u00e9lulas contr\u00e1ctiles del coraz\u00f3n. Sin embargo, un trabajo del\u00a0Centro Nacional de Investigaciones Cardiovasculares Carlos III\u00a0(CNIC) revela que algunas regiones auriculares desarrollan un entorno celular caracter\u00edstico que favorece la persistencia de la arritmia.\u00a0 Estas \u00e1reas se denominan\u00a0regiones impulsoras\u00a0y presentan una actividad el\u00e9ctrica m\u00e1s r\u00e1pida […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-198145","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nLas c\u00e9lulas no contr\u00e1ctiles del coraz\u00f3n son responsables de la persistencia de la arritmia m\u00e1s com\u00fan - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Las c\u00e9lulas no contr\u00e1ctiles del coraz\u00f3n son responsables de la persistencia de la arritmia m\u00e1s com\u00fan\" \/>\n<meta property=\"og:description\" content=\"Tradicionalmente, la fibrilaci\u00f3n auricular se ha considerado un trastorno el\u00e9ctrico de las c\u00e9lulas contr\u00e1ctiles del coraz\u00f3n. Sin embargo, un trabajo del\u00a0Centro Nacional de Investigaciones Cardiovasculares Carlos III\u00a0(CNIC) revela que algunas regiones auriculares desarrollan un entorno celular caracter\u00edstico que favorece la persistencia de la arritmia.\u00a0 Estas \u00e1reas se denominan\u00a0regiones impulsoras\u00a0y presentan una actividad el\u00e9ctrica m\u00e1s r\u00e1pida […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/helloproject.es\/vigilancia\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\/\" \/>\n<meta property=\"og:site_name\" content=\"bip4ex\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-11T11:28:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cdn.agenciasinc.es\/var\/ezwebin_site\/storage\/images\/noticias\/un-modelo-de-ia-para-precisar-el-diagnostico-y-tratamiento-de-arritmias-de-corazon\/11862369-1-esl-MX\/Un-modelo-de-IA-para-precisar-el-diagnostico-y-tratamiento-de-arritmias-de-corazon.jpg\" \/>\n<meta name=\"author\" content=\"Luis Miguel Mej\u00edas Ramos\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Luis Miguel Mej\u00edas Ramos\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\\\/\"},\"author\":{\"name\":\"Luis Miguel Mej\u00edas Ramos\",\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/#\\\/schema\\\/person\\\/3767b0619d59a11570372c821f8619ca\"},\"headline\":\"Las c\u00e9lulas no contr\u00e1ctiles del coraz\u00f3n son responsables de la persistencia de la arritmia m\u00e1s com\u00fan\",\"datePublished\":\"2026-02-11T11:28:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\\\/\"},\"wordCount\":648,\"publisher\":{\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cdn.agenciasinc.es\\\/var\\\/ezwebin_site\\\/storage\\\/images\\\/noticias\\\/un-modelo-de-ia-para-precisar-el-diagnostico-y-tratamiento-de-arritmias-de-corazon\\\/11862369-1-esl-MX\\\/Un-modelo-de-IA-para-precisar-el-diagnostico-y-tratamiento-de-arritmias-de-corazon.jpg\",\"articleSection\":[\"Noticias\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\\\/\",\"url\":\"https:\\\/\\\/helloproject.es\\\/vigilancia\\\/las-celulas-no-contractiles-del-corazon-son-responsables-de-la-persistencia-de-la-arritmia-mas-comun\\\/\",\"name\":\"Las c\u00e9lulas no contr\u00e1ctiles del coraz\u00f3n son responsables de la persistencia de la arritmia m\u00e1s com\u00fan - 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