{"id":199271,"date":"2026-02-26T14:28:11","date_gmt":"2026-02-26T13:28:11","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/la-combinacion-de-dos-farmacos-en-una-sola-pastilla-diaria-simplifica-el-tratamiento-inicial-contra-el-vih\/"},"modified":"2026-02-26T14:28:11","modified_gmt":"2026-02-26T13:28:11","slug":"la-combinacion-de-dos-farmacos-en-una-sola-pastilla-diaria-simplifica-el-tratamiento-inicial-contra-el-vih","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/la-combinacion-de-dos-farmacos-en-una-sola-pastilla-diaria-simplifica-el-tratamiento-inicial-contra-el-vih\/","title":{"rendered":"La combinaci\u00f3n de dos f\u00e1rmacos en una sola pastilla diaria simplifica el tratamiento inicial contra el VIH"},"content":{"rendered":"

Un ensayo cl\u00ednico en fase 3 demuestra que la combinaci\u00f3n de dos medicamentos antivirales en una sola pastilla diaria es un tipo de terapia igual de efectiva que los tratamientos iniciales cl\u00e1sicos para personas con VIH.\u00a0<\/p>\n

Este nuevo f\u00e1rmaco se compone de doravirina e islatravir y ofrece una nueva l\u00ednea terap\u00e9utica para pacientes con intolerancias o alguna resistencia a medicamentos de la familia de los inhibidores de la integrasa. El trabajo ha sido liderado por el Hospital Universitario de Bonn (Alemania) y se ha publicado en\u00a0The Lancet HIV.<\/p>\n

Los expertos vieron que la carga viral del 90% de los participantes de ambos grupos era indetectable y observaron una recuperaci\u00f3n de las c\u00e9lulas CD4 del sistema inmunitario<\/p>\n

Para saberlo, el estudio incluy\u00f3 a 756 personas seropositivas que iniciaban su primer tratamiento tras el diagn\u00f3stico. La mitad recibi\u00f3 la combinaci\u00f3n de estos dos f\u00e1rmacos mientras que al resto se le administr\u00f3 una triple terapia estandarizada, basada en bictegravir, emtricitabina y tenofovir alafenamida.<\/p>\n

Despu\u00e9s de un a\u00f1o, los expertos vieron que la carga viral del 90 % de los participantes de ambos grupos era indetectable y observaron una recuperaci\u00f3n de las c\u00e9lulas CD4 del sistema inmunitario. Los resultados fueron consistentes independientemente de la carga del virus\u00a0o del estado inmunol\u00f3gico.\u00a0<\/p>\n


\n \"La
\n <\/a><\/p>\n

<\/a><\/p>\n

La historia oculta del sida: c\u00f3mo el VIH surgi\u00f3 en \u00c1frica y cruz\u00f3 el mundo sin ser detectado<\/h3>\n

<\/p>\n


\n Javier Yanes
\n <\/a> <\/p>\n

<\/a><\/p>\n

Menor exposici\u00f3n a f\u00e1rmacos<\/h2>\n

Hoy en d\u00eda, la mayor\u00eda de los tratamientos iniciales incluyen inhibidores de la integrasa, y aunque ya existen algunas dobles terapias, se suelen basar habitualmente en esta familia de f\u00e1rmacos.\u00a0<\/p>\n

Por ello, disponer de opciones que no dependan de estos medicamentos ampl\u00eda el abanico terap\u00e9utico en caso de resistencias o intolerancias.\u00a0<\/p>\n

El\u00a0islatravir\u00a0es un compuesto muy potente y con una actividad prolongada en el tiempo, lo que podr\u00eda facilitar pautas m\u00e1s espaciadas<\/p>\n

Seg\u00fan expresa uno de los autores del trabajo e investigador principal de IrsiCaixa, Roger Paredes, este estudio demuestra que existen v\u00edas terap\u00e9uticas m\u00e1s simples, con menos f\u00e1rmacos y con la misma eficacia virol\u00f3gica. \u201cLa combinaci\u00f3n de ambos medicamentos\u2013 doravirina e islatravir\u2013\u00a0 ha demostrado una efectividad comparable a la triple terapia en perfiles cl\u00ednicos diversos\u201d, subraya.\u00a0<\/p>\n

Concretamente, el islatravir es un compuesto muy potente y con una actividad prolongada en el tiempo, lo que podr\u00eda facilitar pautas m\u00e1s espaciadas, como un comprimido a la semana o una inyecci\u00f3n subcut\u00e1nea cada seis meses, tal y como apunta el investigador.<\/p>\n

Los resultados refuerzan el desarrollo de estrategias con f\u00e1rmacos de larga duraci\u00f3n y\u00a0abre el camino hacia tratamientos contra el VIH m\u00e1s simples, flexibles y personalizados.<\/p>\n

Referencia:<\/p>\n

Rockstroh, J. et al.Fixed-dose daily doravirine (100 mg) with islatravir (0\u00b725 mg) versus bictegravir, emtricitabine, and tenofovir alafenamide for initial HIV-1 therapy: 48-week results of a phase 3, randomised, controlled, double-blind, non-inferiority trial.\u00a0The Lancet HIV<\/a>. 2025<\/p>","protected":false},"excerpt":{"rendered":"

Un ensayo cl\u00ednico en fase 3 demuestra que la combinaci\u00f3n de dos medicamentos antivirales en una sola pastilla diaria es un tipo de terapia igual de efectiva que los tratamientos iniciales cl\u00e1sicos para personas con VIH.\u00a0 Este nuevo f\u00e1rmaco se compone de doravirina e islatravir y ofrece una nueva l\u00ednea terap\u00e9utica para pacientes con intolerancias […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-199271","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nLa combinaci\u00f3n de dos f\u00e1rmacos en una sola pastilla diaria simplifica el tratamiento inicial contra el VIH - 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