{"id":199725,"date":"2026-03-03T23:47:41","date_gmt":"2026-03-03T22:47:41","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/identifican-una-diana-terapeutica-para-frenar-la-propagacion-de-los-coronavirus-2\/"},"modified":"2026-03-03T23:47:41","modified_gmt":"2026-03-03T22:47:41","slug":"identifican-una-diana-terapeutica-para-frenar-la-propagacion-de-los-coronavirus-2","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/identifican-una-diana-terapeutica-para-frenar-la-propagacion-de-los-coronavirus-2\/","title":{"rendered":"Identifican una diana terap\u00e9utica para frenar la propagaci\u00f3n de los coronavirus"},"content":{"rendered":"

Los coronavirus no solo utilizan la maquinaria de las c\u00e9lulas humanas que infectan: la modifican para tener condiciones \u00f3ptimas para fabricar prote\u00ednas virales y as\u00ed propagarse con mayor rapidez.<\/p>\n

Esta es la principal conclusi\u00f3n de un estudio de la Universidad Pompeu Fabra publicado en Nature Communications<\/a>. El trabajo identifica unas enzimas que modifican los ARN de transferencia (ARNt) \u2013peque\u00f1as piezas celulares necesarias para la construcci\u00f3n de prote\u00ednas\u2013, como elementos clave para la infecci\u00f3n por coronavirus. Estas enzimas se activan por la respuesta al estr\u00e9s que supone la infecci\u00f3n v\u00edrica y podr\u00edan constituir una nueva diana terap\u00e9utica para desarrollar f\u00e1rmacos antivirales de amplio espectro contra los coronavirus.<\/p>\n

<\/p>\n

Los coronavirus son muy peligrosos por su capacidad de generar nuevas variantes capaces de infectar a humanos tras circular en reservorios animales<\/p>\n

Juana D\u00edez, UPF
\n<\/p>\n

En los \u00faltimos 25 a\u00f1os el mundo ha presenciado tres grandes brotes de enfermedades respiratorias causadas por coronavirus que han pasado de animales a humanos. El SARS-CoV-1 en 2002, el MERS en 2012 y el SARS-CoV-2 en 2019. Mientras que las dos primeras causaron epidemias, el SARS-CoV-2 desencaden\u00f3 una pandemia que caus\u00f3 m\u00e1s de 7 millones de muertes.<\/p>\n

\u201cLos coronavirus son muy peligrosos por su capacidad de generar nuevas variantes capaces de infectar a humanos tras circular en reservorios animales\u201d, cuenta Juana D\u00edez, directora del Grupo de Investigaci\u00f3n en Virolog\u00eda Molecular de la Universidad Pompeu Fabra, que ha liderado la investigaci\u00f3n. \u201cActualmente no tenemos ning\u00fan f\u00e1rmaco antiviral de amplio espectro eficaz frente a los coronavirus. As\u00ed que cuando emerja un nuevo coronavirus, un escenario considerado muy probable en la comunidad cient\u00edfica, estaremos como a finales del 2019, cuando no ten\u00edamos f\u00e1rmacos para controlar la propagaci\u00f3n\u201d.<\/p>\n

\u00a0\u201cCuriosamente, los coronavirus necesitan unos ARNt que est\u00e1n en baja concentraci\u00f3n en las c\u00e9lulas. Por eso nos preguntamos, \u00bfc\u00f3mo puede un virus propagarse tan deprisa dentro de una c\u00e9lula donde no abundan los ARNt que necesita para fabricar sus prote\u00ednas virales?\u201d, explica Elena Muscolino, primera autora del trabajo.<\/p>\n


\n \"Revelan
\n <\/a><\/p>\n

<\/a><\/p>\n

Revelan que la parte menos conocida de la prote\u00edna Spike del coronavirus es vital para la infecci\u00f3n<\/h3>\n

<\/p>\n


\n SINC
\n <\/a> <\/p>\n

<\/a><\/p>\n

Aprovechar el cambio<\/h2>\n

El estudio muestra que la infecci\u00f3n provoca un estr\u00e9s que modifica qu\u00edmicamente los ARNt y cambia el funcionamiento de la maquinaria celular. As\u00ed, la c\u00e9lula deja de estar optimizada para producir sus propias prote\u00ednas y pasa a tener las condiciones ideales para responder al estr\u00e9s.\u00a0<\/p>\n

Los coronavirus han aprovechado esta situaci\u00f3n, ya que \u201cpara fabricar prote\u00ednas de respuesta al estr\u00e9s se necesitan los mismos ARNt que necesitan los coronavirus para fabricar sus prote\u00ednas virales\u201d, explica Mireia Puig, tambi\u00e9n autora del trabajo.\u00a0<\/p>\n

Este reajuste, impulsado por enzimas celulares que modifican los ARNt, permite que los coronavirus aceleren la producci\u00f3n de sus prote\u00ednas sin necesidad de generar nueva maquinaria, simplemente alterando la que ya existe. \u201cComo los cambios en los ARNt son modificaciones de la maquinaria que ya tiene la c\u00e9lula y no generaci\u00f3n de nuevas \u2018piezas celulares\u2019, la producci\u00f3n de prote\u00ednas virales se da r\u00e1pidamente y los coronavirus pueden propagarse muy deprisa\u201d, detalla Muscolino.<\/p>\n

<\/p>\n

La enzima de modificaci\u00f3n de los ARNt es una candidata que promete para desarrollar antivirales de amplio espectro capaces de frenar la propagaci\u00f3n de los coronavirus<\/p>\n

Juana D\u00edez, UPF
\n<\/p>\n

La modificaci\u00f3n de los ARNt se ha observado tanto en SARS-CoV-2, asociado a infecciones graves, como en HCoV-OC43, que suele causar cuadros muy leves parecidos a un resfriado. Por tanto, podr\u00eda tratarse de una estrategia com\u00fan entre distintos coronavirus. Adem\u00e1s, cuando se bloquea la actividad de estas enzimas modificadoras, la producci\u00f3n de prote\u00ednas virales disminuye de forma significativa.\u00a0<\/p>\n

\u201cLa enzima de modificaci\u00f3n de los ARNt es una candidata que promete para desarrollar antivirales de amplio espectro capaces de frenar la propagaci\u00f3n de los coronavirus\u201d, se\u00f1ala D\u00edez. Y a\u00f1ade: \u201cUn f\u00e1rmaco de este tipo nos permitir\u00eda contener las infecciones causadas por nuevos coronavirus desde sus fases iniciales y evitar su r\u00e1pida expansi\u00f3n, y por tanto, la generaci\u00f3n de nuevas pandemias\u201d.<\/p>\n

\u00a0Este trabajo, liderado por la Universidad Pompeu Fabra, se ha realizado en colaboraci\u00f3n con los grupos de investigaci\u00f3n dirigidos por Arvind H. Patel y Alfredo Castell\u00f3 (Universidad de Glasgow), Rafael Sanju\u00e1n (Instituto de Biolog\u00eda Integrativa de Sistemas, Valencia) y Miguel Chill\u00f3n (Universidad Aut\u00f3noma de Barcelona).<\/p>\n

Referencia:<\/p>\n

Muscolino E, Puig-Torrents M, Buigues Bisquert J, Correa Mendonca D, Tall\u00f3-Parra M, Perez-Vilaro G,\u00a0et al. Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression.\u00a0Nature Communications<\/a>\u00a0(2026).<\/p>","protected":false},"excerpt":{"rendered":"

Los coronavirus no solo utilizan la maquinaria de las c\u00e9lulas humanas que infectan: la modifican para tener condiciones \u00f3ptimas para fabricar prote\u00ednas virales y as\u00ed propagarse con mayor rapidez. Esta es la principal conclusi\u00f3n de un estudio de la Universidad Pompeu Fabra publicado en Nature Communications. El trabajo identifica unas enzimas que modifican los ARN […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-199725","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nIdentifican una diana terap\u00e9utica para frenar la propagaci\u00f3n de los coronavirus - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/identifican-una-diana-terapeutica-para-frenar-la-propagacion-de-los-coronavirus-2\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifican una diana terap\u00e9utica para frenar la propagaci\u00f3n de los coronavirus\" \/>\n<meta property=\"og:description\" content=\"Los coronavirus no solo utilizan la maquinaria de las c\u00e9lulas humanas que infectan: la modifican para tener condiciones \u00f3ptimas para fabricar prote\u00ednas virales y as\u00ed propagarse con mayor rapidez. 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