{"id":200804,"date":"2026-03-18T17:28:13","date_gmt":"2026-03-18T16:28:13","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/logran-reprogramar-celulas-inmunitarias-contra-el-cancer-dentro-del-organismo\/"},"modified":"2026-03-18T17:28:13","modified_gmt":"2026-03-18T16:28:13","slug":"logran-reprogramar-celulas-inmunitarias-contra-el-cancer-dentro-del-organismo","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/logran-reprogramar-celulas-inmunitarias-contra-el-cancer-dentro-del-organismo\/","title":{"rendered":"Logran reprogramar c\u00e9lulas inmunitarias contra el c\u00e1ncer dentro del organismo"},"content":{"rendered":"

La terapia con c\u00e9lulas CAR-T es sin duda una de las armas m\u00e1s potentes contra ciertos c\u00e1nceres como la leucemia, pero a\u00fan requiere de un proceso complejo: los m\u00e9dicos extraen c\u00e9lulas inmunitarias del paciente, las env\u00edan a instalaciones especializadas para su reprogramaci\u00f3n gen\u00e9tica y, semanas despu\u00e9s, las introducen de nuevo en el torrente sangu\u00edneo. Este procedimiento, aunque revolucionario,\u00a0puede costar cientos de miles de euros a los sistemas sanitarios, lo que deja fuera a muchos pacientes cuyo c\u00e1ncer progresa durante esta espera.<\/p>\n

Ahora, un equipo de cient\u00edficos de la Universidad de California en San Francisco (UCSF) ha desarrollado un m\u00e9todo para reprogramar estas c\u00e9lulas directamente dentro del cuerpo. El avance, publicado esta semana en la revista Nature<\/a>, supone la primera vez que se logra integrar una secuencia larga de ADN en un lugar espec\u00edfico de las c\u00e9lulas T humanas sin haberlas extra\u00eddo nunca del organismo.<\/p>\n

<\/p>\n

Es el comienzo de una gran ola de nuevas terapias que ser\u00e1n verdaderamente transformadoras y salvar\u00e1n muchas vidas<\/p>\n

Justin Eyquem, UCSF
\n<\/p>\n

\u201cCreo que esto es solo el comienzo de una gran ola de nuevas terapias que ser\u00e1n verdaderamente transformadoras y salvar\u00e1n muchas vidas\u201d, afirma\u00a0Justin Eyquem, profesor asociado de medicina en la UCSF y autor principal del estudio. Seg\u00fan los investigadores, este enfoque de precisi\u00f3n super\u00f3 al m\u00e9todo est\u00e1ndar de integraci\u00f3n aleatoria de ADN mediante virus, lo que supone un hito para la terapia g\u00e9nica.<\/p>\n

<\/a><\/p>\n

Tijeras moleculares dirigidas<\/h2>\n

Para conseguir que la edici\u00f3n ocurriera solo donde era necesario, los cient\u00edficos dise\u00f1aron un sistema de doble part\u00edcula que transporta la maquinaria CRISPR Cas9. La primera part\u00edcula est\u00e1 recubierta con anticuerpos que solo se unen a la prote\u00edna CD3, presente exclusivamente en la superficie de las c\u00e9lulas T. La segunda transporta el ADN que codifica el receptor CAR y las instrucciones para insertarlo en un punto exacto del genoma.<\/p>\n

Este nivel de control es fundamental. \u201cCuando se fabrican estas c\u00e9lulas fuera del cuerpo, se puede realizar un control de calidad exhaustivo\u201d, explica Eyquem. \u201cDentro del organismo no podemos hacer eso, as\u00ed que tuvimos que optimizar el enfoque de antemano para evitar alterar cualquier otra c\u00e9lula\u201d.<\/p>\n


\n \"Dos
\n <\/a><\/p>\n

<\/a><\/p>\n

Dos pacientes permanecen una d\u00e9cada libres de leucemia tras un tratamiento con c\u00e9lulas T CAR<\/h3>\n

<\/p>\n


\n Ana Hernando
\n <\/a> <\/p>\n

<\/a><\/p>\n

Resultados en dos semanas<\/h2>\n

Los experimentos se realizaron en\u00a0ratones con sistemas inmunitarios humanizados a los que se les indujo una leucemia agresiva. Una sola inyecci\u00f3n del sistema de doble part\u00edcula elimin\u00f3 todo rastro detectable de c\u00e1ncer en casi todos los ejemplares en solo dos semanas. Adem\u00e1s, las c\u00e9lulas CAR-T generadas in vivo mostraron una capacidad de proliferaci\u00f3n superior a las fabricadas en laboratorio.<\/p>\n

Las c\u00e9lulas CAR-T generadas\u00a0in vivo\u00a0mostraron una capacidad de proliferaci\u00f3n superior a las fabricadas en laboratorio<\/p>\n

\u201cLo que fue especialmente notable es que las c\u00e9lulas que estamos generando en el cuerpo parecen mejores que las que fabricamos en el laboratorio\u201d, se\u00f1ala el investigador. \u201cCreemos que al sacarlas del organismo pierden parte de su capacidad de autorrenovaci\u00f3n, algo que no ocurre aqu\u00ed\u201d.<\/p>\n

Adem\u00e1s del \u00e9xito en c\u00e1nceres hematol\u00f3gicos como el mieloma m\u00faltiple, el tratamiento funcion\u00f3 contra un tumor s\u00f3lido de sarcoma, un tipo de c\u00e1ncer que hist\u00f3ricamente ha resistido a la terapia CAR-T. Aunque la tecnolog\u00eda todav\u00eda debe escalarse para su uso en humanos, los autores conf\u00edan en que este avance democratice el acceso a estas terapias al eliminar la necesidad de infraestructuras complejas y reducir dr\u00e1sticamente los tiempos de espera.<\/p>\n

Referencia:<\/p>\n

Nyberg et al, \u201cIn vivo site-specific engineering to reprogram T cells\u201d.\u00a0Nature<\/a>, 2026.<\/p>","protected":false},"excerpt":{"rendered":"

La terapia con c\u00e9lulas CAR-T es sin duda una de las armas m\u00e1s potentes contra ciertos c\u00e1nceres como la leucemia, pero a\u00fan requiere de un proceso complejo: los m\u00e9dicos extraen c\u00e9lulas inmunitarias del paciente, las env\u00edan a instalaciones especializadas para su reprogramaci\u00f3n gen\u00e9tica y, semanas despu\u00e9s, las introducen de nuevo en el torrente sangu\u00edneo. Este […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-200804","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nLogran reprogramar c\u00e9lulas inmunitarias contra el c\u00e1ncer dentro del organismo - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/logran-reprogramar-celulas-inmunitarias-contra-el-cancer-dentro-del-organismo\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Logran reprogramar c\u00e9lulas inmunitarias contra el c\u00e1ncer dentro del organismo\" \/>\n<meta property=\"og:description\" content=\"La terapia con c\u00e9lulas CAR-T es sin duda una de las armas m\u00e1s potentes contra ciertos c\u00e1nceres como la leucemia, pero a\u00fan requiere de un proceso complejo: los m\u00e9dicos extraen c\u00e9lulas inmunitarias del paciente, las env\u00edan a instalaciones especializadas para su reprogramaci\u00f3n gen\u00e9tica y, semanas despu\u00e9s, las introducen de nuevo en el torrente sangu\u00edneo. 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