{"id":203000,"date":"2026-04-15T11:28:44","date_gmt":"2026-04-15T10:28:44","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/los-medicamentos-glp-1-mejoran-la-salud-hepatica-aunque-no-se-pierda-peso\/"},"modified":"2026-04-15T11:28:44","modified_gmt":"2026-04-15T10:28:44","slug":"los-medicamentos-glp-1-mejoran-la-salud-hepatica-aunque-no-se-pierda-peso","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/los-medicamentos-glp-1-mejoran-la-salud-hepatica-aunque-no-se-pierda-peso\/","title":{"rendered":"Los medicamentos GLP-1 mejoran la salud hep\u00e1tica aunque no se pierda peso"},"content":{"rendered":"

Los f\u00e1rmacos basados en el compuesto GLP-1 han revolucionado el tratamiento de enfermedades metab\u00f3licas como la\u00a0diabetes\u00a0y la\u00a0obesidad, y en los \u00faltimos a\u00f1os han demostrado beneficios que van mucho m\u00e1s all\u00e1 del peso.<\/p>\n

Ahora, un estudio realizado entre la Universidad de Toronto y el Centro de Investigaci\u00f3n en Medicina Molecular (ambas en Canad\u00e1), y publicado en\u00a0Cell Metabolism, demuestra que la semaglutida ejerce efectos directos sobre el\u00a0h\u00edgado, independientemente de la p\u00e9rdida de grasa, y revela su eficacia frente a la enfermedad hep\u00e1tica metab\u00f3lica.<\/p>\n

<\/p>\n

El estudio abre la puerta a desarrollar terapias m\u00e1s espec\u00edficas y a determinar qu\u00e9 pacientes pueden beneficiarse m\u00e1s de estos tratamientos<\/p>\n

Mar\u00eda Jes\u00fas Gonz\u00e1lez Rell\u00e1n, autora principal del estudio e investigadora del CiMUS.
\n<\/p>\n

En concreto, esta investigaci\u00f3n demuestra que el receptor de GLP-1 \u2013la diana terap\u00e9utica de la semaglutida\u2013 se encuentra en un tipo muy espec\u00edfico de\u00a0c\u00e9lulas endoteliales del h\u00edgado\u00a0que act\u00faan como coordinadoras del funcionamiento hep\u00e1tico.<\/p>\n

Cuando la semaglutida activa este receptor, se desencadena una red de se\u00f1ales que reduce la inflamaci\u00f3n, disminuye la\u00a0fibrosis\u00a0y favorece la recuperaci\u00f3n del tejido en este \u00f3rgano tan relevante.<\/p>\n

El hallazgo supone un cambio relevante en la comprensi\u00f3n de c\u00f3mo act\u00faan los f\u00e1rmacos basados en GLP-1. Seg\u00fan la autora principal del estudio e investigadora del CiMUS,\u00a0Mar\u00eda Jes\u00fas Gonz\u00e1lez Rell\u00e1n: \u201cIdentificar estos mecanismos directos ayuda a entender mejor su eficacia y abre la puerta a desarrollar terapias m\u00e1s espec\u00edficas y a determinar qu\u00e9 pacientes pueden beneficiarse m\u00e1s de estos tratamientos\u201d.<\/p>\n


\n \"La
\n <\/a><\/p>\n

<\/a><\/p>\n

La semaglutida no es para todos: desigualdades en el acceso a f\u00e1rmacos contra la obesidad<\/h3>\n

<\/p>\n


\n Marcos D. Oliveros
\n <\/a> <\/p>\n

<\/a><\/p>\n

\u00a0El 30 % de la poblaci\u00f3n<\/h2>\n

La enfermedad hep\u00e1tica metab\u00f3lica afecta al 30 % de la poblaci\u00f3n mundial y, hasta hace poco, no contaba con tratamientos eficaces. Dado que est\u00e1 estrechamente relacionada con la obesidad y la diabetes, se asum\u00eda que la\u00a0mejor\u00eda observada\u00a0con los f\u00e1rmacos era consecuencia indirecta de la p\u00e9rdida de peso.\u00a0<\/p>\n

<\/p>\n

Nuestros resultados muestran que la semaglutida act\u00faa directamente sobre el h\u00edgado al activar c\u00e9lulas que coordinan la respuesta frente a la inflamaci\u00f3n y la fibrosis<\/p>\n

Mar\u00eda Jes\u00fas Gonz\u00e1lez Rell\u00e1n, autora principal del estudio e investigadora del CiMUS.
\n<\/p>\n

No obstante, ensayos cl\u00ednicos recientes han mostrado resultados inesperados: algunos pacientes mejoraban incluso antes de\u00a0adelgazar\u00a0o sin hacerlo de forma significativa, lo que suger\u00eda la existencia de mecanismos adicionales.<\/p>\n

\u201cDurante a\u00f1os se asum\u00eda que la mejor\u00eda hep\u00e1tica era consecuencia de la p\u00e9rdida de peso, pero nuestros resultados muestran que la semaglutida act\u00faa directamente sobre el h\u00edgado al activar c\u00e9lulas que coordinan la respuesta frente a la inflamaci\u00f3n y la fibrosis\u201d, explica Gonz\u00e1lez Rell\u00e1n.<\/p>\n

\u201cEste estudio refuerza, por tanto, la idea de que la semaglutida no solo ayuda a perder peso, sino que ejerce una acci\u00f3n protectora sobre el h\u00edgado, lo que consolida su papel como herramienta clave frente a enfermedades metab\u00f3licas complejas\u201d, tal y como concluye la experta.<\/p>\n

Referencia:\u00a0<\/p>\n

Rell\u00e1n. M.J. \u00a0et al. The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors. Cell Metabolism<\/a>\u00a02026<\/p>","protected":false},"excerpt":{"rendered":"

Los f\u00e1rmacos basados en el compuesto GLP-1 han revolucionado el tratamiento de enfermedades metab\u00f3licas como la\u00a0diabetes\u00a0y la\u00a0obesidad, y en los \u00faltimos a\u00f1os han demostrado beneficios que van mucho m\u00e1s all\u00e1 del peso. Ahora, un estudio realizado entre la Universidad de Toronto y el Centro de Investigaci\u00f3n en Medicina Molecular (ambas en Canad\u00e1), y publicado en\u00a0Cell […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-203000","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nLos medicamentos GLP-1 mejoran la salud hep\u00e1tica aunque no se pierda peso - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/los-medicamentos-glp-1-mejoran-la-salud-hepatica-aunque-no-se-pierda-peso\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Los medicamentos GLP-1 mejoran la salud hep\u00e1tica aunque no se pierda peso\" \/>\n<meta property=\"og:description\" content=\"Los f\u00e1rmacos basados en el compuesto GLP-1 han revolucionado el tratamiento de enfermedades metab\u00f3licas como la\u00a0diabetes\u00a0y la\u00a0obesidad, y en los \u00faltimos a\u00f1os han demostrado beneficios que van mucho m\u00e1s all\u00e1 del peso. 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