{"id":203260,"date":"2026-04-21T11:28:07","date_gmt":"2026-04-21T10:28:07","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/asocian-el-tabaco-la-dieta-y-los-pesticidas-con-el-cancer-colorrectal-en-jovenes\/"},"modified":"2026-04-21T11:28:07","modified_gmt":"2026-04-21T10:28:07","slug":"asocian-el-tabaco-la-dieta-y-los-pesticidas-con-el-cancer-colorrectal-en-jovenes","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/asocian-el-tabaco-la-dieta-y-los-pesticidas-con-el-cancer-colorrectal-en-jovenes\/","title":{"rendered":"Asocian el tabaco, la dieta y los pesticidas con el c\u00e1ncer colorrectal en j\u00f3venes"},"content":{"rendered":"

El c\u00e1ncer colorrectal actualmente es el segundo responsable del mayor n\u00famero de muertes por c\u00e1ncer a nivel mundial (9,3 %), solo por detr\u00e1s del de pulm\u00f3n. Seg\u00fan la Sociedad Espa\u00f1ola de Oncolog\u00eda M\u00e9dica<\/a>, este tumor ser\u00e1 el m\u00e1s diagnosticado en Espa\u00f1a durante 2026, con una estimaci\u00f3n de 44 132 nuevos casos.<\/p>\n

Un nuevo estudio liderado por un equipo de Vall d’Hebron Instituto de Oncolog\u00eda (VHIO) relaciona los cambios epigen\u00e9ticos provocados por dieta, tabaco y exposici\u00f3n a pesticidas con el desarrollo de c\u00e1ncer de colon en personas menores de 50 a\u00f1os.<\/p>\n

El estudio analiz\u00f3 firmas epigen\u00e9ticas, patrones espec\u00edficos de modificaciones qu\u00edmicas en el ADN influenciados por el mundo que nos rodea<\/p>\n

El estudio, publicado en Nature Medicine, es el primero que aborda el impacto de factores no gen\u00e9ticos en este tumor de inicio temprano a trav\u00e9s de firmas epigen\u00e9ticas. Es decir, a trav\u00e9s de los patrones espec\u00edficos de modificaciones qu\u00edmicas en el ADN influenciados por el mundo que nos rodea.<\/p>\n

Los investigadores compararon las marcas epigen\u00e9ticas de metilaci\u00f3n en pacientes con c\u00e1ncer colorrectal de aparici\u00f3n temprana con las de pacientes de inicio tard\u00edo. Confirmaron factores de riesgo previamente identificados como dieta o tabaco.<\/p>\n

Tambi\u00e9n encontraron una asociaci\u00f3n significativa con el picloram, un herbicida de uso extendido. Demostraron, a partir de datos poblacionales, que los condados de Estados Unidos con mayor utilizaci\u00f3n de este pesticida registran tasas m\u00e1s altas de c\u00e1ncer colorrectal\u00a0 en adultos j\u00f3venes, incluso al tener en cuenta factores socioecon\u00f3micos y el uso de otros pesticidas.<\/p>\n

<\/p>\n

El c\u00e1ncer de colorrectal de aparici\u00f3n temprana tiene caracter\u00edsticas cl\u00ednicas y patol\u00f3gicas diferenciadas en comparaci\u00f3n con el c\u00e1ncer colorrectal en pacientes de mayor edad<\/p>\n

Jose Antonio Seoane, VHIO
\n<\/p>\n

\u201cEl c\u00e1ncer colorrectal deaparici\u00f3n temprana tiene caracter\u00edsticas cl\u00ednicas y patol\u00f3gicas diferenciadas en comparaci\u00f3n con este tumor en pacientes de mayor edad. Sin embargo, a nivel gen\u00f3mico, las alteraciones moleculares son similares y no se han identificado alteraciones espec\u00edficas\u201d, explica Jose Antonio Seoane, jefe del Grupo de Biolog\u00eda Computacional del C\u00e1ncer del VHIO e investigador s\u00e9nior del estudio. \u201cLas causas del aumento de la incidencia del c\u00e1ncer colorrectal en adultos j\u00f3venes no est\u00e1n claras\u201d.<\/p>\n


\n \"Un
\n <\/a><\/p>\n

<\/a><\/p>\n

Un estilo de vida saludable reduce casi a la mitad el riesgo de c\u00e1ncer colorrectal <\/h3>\n

<\/p>\n


\n SINC
\n <\/a> <\/p>\n

<\/a><\/p>\n

La influencia del exposoma<\/h2>\n

Las hip\u00f3tesis emergentes sugieren que las exposiciones ambientales y relacionadas con el estilo de vida, conocidas como el exposoma, podr\u00edan desempe\u00f1ar un papel clave. Sin embargo, los esfuerzos por identificar factores de riesgo modificables espec\u00edficos del c\u00e1ncer colorrectal temprano han tenido un \u00e9xito limitado.<\/p>\n

La mayor\u00eda de los estudios comparan casos tempranos con controles de la misma edad y detectan los mismos factores de riesgo descritos para el c\u00e1ncer colorrectal de inicio tard\u00edo.<\/p>\n

Algunos de los principales factores que afectan a este tumor en adultos j\u00f3venes son el\u00a0tabaquismo, la dieta o el microbioma<\/p>\n

Entre los factores que pueden afectar al c\u00e1ncer colorrectal temprano, se han estudiado algunos como el tabaquismo, la dieta o el microbioma. El equipo destaca que los resultados tienen algunas limitaciones. Seg\u00fan ellos, se debe en parte a que no siempre se han medido de forma precisa las exposiciones ambientales a lo largo de la vida, lo que dificulta relacionarlas claramente con el riesgo de c\u00e1ncer.<\/p>\n

No obstante, estudios recientes han detectado cambios espec\u00edficos en la metilaci\u00f3n del ADN\u00a0provocados por estas exposiciones. Esto abre nuevas l\u00edneas para entender mejor la enfermedad.<\/p>\n

La principal conclusi\u00f3n de la investigaci\u00f3n es la utilidad de la epigen\u00e9tica como una herramienta para medir la exposici\u00f3n ambiental en los tejidos.\u00a0Los resultados, concluye Seoane, \u201csientan una base s\u00f3lida para abordar las exposiciones ambientales y los factores relacionados con el estilo de vida con el fin de reducir el riesgo, destacando la importancia de impulsar intervenciones preventivas tanto a nivel individual como de pol\u00edticas p\u00fablicas\u201d.<\/p>\n

Referencia:<\/p>\n

Maas, S. et al. Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure. Nat Medicine<\/a> (2026).\u00a0<\/p>","protected":false},"excerpt":{"rendered":"

El c\u00e1ncer colorrectal actualmente es el segundo responsable del mayor n\u00famero de muertes por c\u00e1ncer a nivel mundial (9,3 %), solo por detr\u00e1s del de pulm\u00f3n. Seg\u00fan la Sociedad Espa\u00f1ola de Oncolog\u00eda M\u00e9dica, este tumor ser\u00e1 el m\u00e1s diagnosticado en Espa\u00f1a durante 2026, con una estimaci\u00f3n de 44 132 nuevos casos. Un nuevo estudio liderado […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-203260","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nAsocian el tabaco, la dieta y los pesticidas con el c\u00e1ncer colorrectal en j\u00f3venes - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/asocian-el-tabaco-la-dieta-y-los-pesticidas-con-el-cancer-colorrectal-en-jovenes\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Asocian el tabaco, la dieta y los pesticidas con el c\u00e1ncer colorrectal en j\u00f3venes\" \/>\n<meta property=\"og:description\" content=\"El c\u00e1ncer colorrectal actualmente es el segundo responsable del mayor n\u00famero de muertes por c\u00e1ncer a nivel mundial (9,3 %), solo por detr\u00e1s del de pulm\u00f3n. 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