{"id":204748,"date":"2026-05-28T08:28:07","date_gmt":"2026-05-28T07:28:07","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/degradar-la-proteina-kras-produce-una-marcada-regresion-del-cancer-de-pulmon-en-ratones\/"},"modified":"2026-05-28T08:28:07","modified_gmt":"2026-05-28T07:28:07","slug":"degradar-la-proteina-kras-produce-una-marcada-regresion-del-cancer-de-pulmon-en-ratones","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/degradar-la-proteina-kras-produce-una-marcada-regresion-del-cancer-de-pulmon-en-ratones\/","title":{"rendered":"Degradar la prote\u00edna KRAS produce una marcada regresi\u00f3n del c\u00e1ncer de pulm\u00f3n en ratones"},"content":{"rendered":"

KRAS es uno de los grandes motores del c\u00e1ncer y est\u00e1 alterado en cerca de un tercio de los tumores de pulm\u00f3n m\u00e1s frecuentes. Aunque en los \u00faltimos a\u00f1os han surgido f\u00e1rmacos capaces de bloquearlo, su efecto suele durar poco por la aparici\u00f3n de resistencias. Ahora, un estudio propone ir un paso m\u00e1s all\u00e1: hacer que la propia c\u00e9lula destruya esta prote\u00edna clave.<\/p>\n

El trabajo, liderado por el IRB Barcelona y el Centro de Investigaci\u00f3n del C\u00e1ncer (CSIC, USAL, FICUS), demuestra que destruir KRAS mutada, en lugar de bloquearla, induce una regresi\u00f3n m\u00e1s intensa del tumor en modelos de rat\u00f3n con adenocarcinoma de pulm\u00f3n. Publicado en Cancer Research, el estudio aporta adem\u00e1s una de las primeras descripciones en vivo de c\u00f3mo surgen resistencias frente a terapias basadas en degradaci\u00f3n dirigida.<\/p>\n

<\/p>\n

Los inhibidores de KRAS han supuesto un gran avance, pero las resistencias siguen siendo un problema. Ahora podemos ir un paso m\u00e1s all\u00e1 y hacer que la c\u00e9lula tumoral degrade esta prote\u00edna<\/p>\n

Cristina Mayor-Ruiz (IRB Barcelona)
\n<\/p>\n

\u201cLos inhibidores de KRAS han supuesto un cambio enorme en el tratamiento de algunos c\u00e1nceres, pero las resistencias siguen siendo un gran problema. Ahora estamos entrando en una nueva etapa, en la que no solo podemos inhibir KRAS, sino tambi\u00e9n hacer que la propia c\u00e9lula tumoral lo degrade. El uso secuencial o incluso en combinaci\u00f3n de ambas estrategias farmacol\u00f3gicas podr\u00eda marcar la diferencia\u201d, explica\u00a0Cristina Mayor-Ruiz, investigadora del IRB Barcelona.<\/p>\n

<\/a><\/p>\n

Hacer que la c\u00e9lula elimine KRAS<\/h2>\n

as terapias de degradaci\u00f3n dirigida emplean mol\u00e9culas conocidas como PROTACs que inducen la destrucci\u00f3n de prote\u00ednas concretas. A diferencia de los inhibidores cl\u00e1sicos, no bloquean la actividad de la diana, sino que la eliminan.<\/p>\n

Como a\u00fan no existen PROTACs capaces de degradar directamente la mutaci\u00f3n KRASG12V, el equipo dise\u00f1\u00f3 un modelo experimental: introdujo en las c\u00e9lulas tumorales una etiqueta molecular en la prote\u00edna que permite su reconocimiento y utiliz\u00f3 PROTACs desarrollados en el IRB Barcelona, en colaboraci\u00f3n con el grupo del qu\u00edmico Antoni Riera, que se unen a esa etiqueta y desencadenan su degradaci\u00f3n.<\/p>\n

As\u00ed lograron eliminar KRASG12V en ratones y observar una marcada regresi\u00f3n tumoral. Adem\u00e1s, el modelo puede adaptarse para estudiar otros oncogenes y tipos de c\u00e1ncer.<\/p>\n

<\/p>\n

Las c\u00e9lulas tumorales son extremadamente dependientes de KRAS. Cuando eliminamos la prote\u00edna mutada, dejan de proliferar y entran en apoptosis, incluso sin la intervenci\u00f3n del sistema inmunitario<\/p>\n

David Santamar\u00eda (Centro de Investigaci\u00f3n del C\u00e1ncer)
\n<\/p>\n

\u201cLas c\u00e9lulas tumorales son extremadamente dependientes de KRAS. Cuando eliminamos la prote\u00edna mutada, dejan de proliferar y entran en apoptosis, incluso sin la intervenci\u00f3n del sistema inmunitario\u201d, se\u00f1ala David Santamar\u00eda, investigador del Centro de Investigaci\u00f3n del C\u00e1ncer.<\/p>\n

Aunque los tumores tratados mostraron mayor infiltraci\u00f3n de c\u00e9lulas inmunitarias, los experimentos en ratones inmunodeficientes indican que la regresi\u00f3n inicial depende sobre todo de cambios intr\u00ednsecos del tumor y no de la respuesta inmune.<\/p>\n

En conjunto, los resultados apuntan a que la degradaci\u00f3n dirigida puede generar respuestas m\u00e1s profundas y duraderas que los inhibidores actuales.<\/p>\n


\n \"Un
\n <\/a><\/p>\n

<\/a><\/p>\n

Un mapa epigen\u00e9tico revela las conversaciones celulares que inician el c\u00e1ncer de p\u00e1ncreas<\/h3>\n

<\/p>\n


\n SINC
\n <\/a> <\/p>\n

<\/a><\/p>\n

Resistencias diferentes a las conocidas<\/h2>\n

El estudio tambi\u00e9n analiza c\u00f3mo aparecen resistencias a estos nuevos f\u00e1rmacos en tumores vivos. Los mecanismos detectados difieren de los descritos con inhibidores de KRAS.<\/p>\n

En lugar de mutaciones adicionales en KRAS o reactivaci\u00f3n de rutas de se\u00f1alizaci\u00f3n, las c\u00e9lulas tumorales alteran la maquinaria encargada de degradar prote\u00ednas. Con el tiempo, esto impide que KRAS siga elimin\u00e1ndose de manera eficaz.<\/p>\n

<\/p>\n

Es una forma completamente distinta de resistencia. El tumor sigue dependiendo de KRAS, pero aprende a sabotear el sistema que lo destruye<\/p>\n

In\u00e9s M. Garc\u00eda-P\u00e9rez (IRB Barcelona)
\n<\/p>\n

\u201cEs una forma completamente distinta de resistencia. El tumor sigue dependiendo de KRAS, pero aprende a sabotear el sistema que lo destruye\u201d, afirma In\u00e9s M. Garc\u00eda-P\u00e9rez, investigadora del IRB Barcelona.<\/p>\n

<\/a><\/p>\n

Colaboraci\u00f3n y financiaci\u00f3n<\/h2>\n

El trabajo es fruto de la colaboraci\u00f3n entre los equipos de Cristina Mayor-Ruiz en el IRB Barcelona y David Santamar\u00eda en el Centro de Investigaci\u00f3n del C\u00e1ncer (CSIC, USAL, FICUS), con participaci\u00f3n de investigadores de varias instituciones nacionales e internacionales.<\/p>\n

La investigaci\u00f3n ha contado con financiaci\u00f3n del Ministerio de Ciencia e Innovaci\u00f3n, el Consejo Europeo de Investigaci\u00f3n, la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer, la Generalitat de Catalunya, el programa Next Generation de la Uni\u00f3n Europea, la Fundaci\u00f3n \u201cla Caixa\u201d y FarmaIndustria.<\/p>\n

Referencia:<\/p>\n

Alberto Mart\u00edn, In\u00e9s M. Garc\u00eda-P\u00e9rez et al.\u00a0\u201cTargeted KRASG12V degradation in vivo elicits lung adenocarcinoma regression with subsequent relapse from dysregulated proteolysis\u201d.\u00a0Cancer Research (2026).<\/p>","protected":false},"excerpt":{"rendered":"

KRAS es uno de los grandes motores del c\u00e1ncer y est\u00e1 alterado en cerca de un tercio de los tumores de pulm\u00f3n m\u00e1s frecuentes. Aunque en los \u00faltimos a\u00f1os han surgido f\u00e1rmacos capaces de bloquearlo, su efecto suele durar poco por la aparici\u00f3n de resistencias. Ahora, un estudio propone ir un paso m\u00e1s all\u00e1: hacer […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-204748","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nDegradar la prote\u00edna KRAS produce una marcada regresi\u00f3n del c\u00e1ncer de pulm\u00f3n en ratones - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/degradar-la-proteina-kras-produce-una-marcada-regresion-del-cancer-de-pulmon-en-ratones\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Degradar la prote\u00edna KRAS produce una marcada regresi\u00f3n del c\u00e1ncer de pulm\u00f3n en ratones\" \/>\n<meta property=\"og:description\" content=\"KRAS es uno de los grandes motores del c\u00e1ncer y est\u00e1 alterado en cerca de un tercio de los tumores de pulm\u00f3n m\u00e1s frecuentes. 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