{"id":204897,"date":"2026-06-02T10:28:33","date_gmt":"2026-06-02T09:28:33","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/la-obesidad-deja-huellas-epigeneticas-en-el-adn-de-los-ninos\/"},"modified":"2026-06-02T10:28:33","modified_gmt":"2026-06-02T09:28:33","slug":"la-obesidad-deja-huellas-epigeneticas-en-el-adn-de-los-ninos","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/la-obesidad-deja-huellas-epigeneticas-en-el-adn-de-los-ninos\/","title":{"rendered":"La obesidad deja huellas epigen\u00e9ticas en el ADN de los ni\u00f1os"},"content":{"rendered":"

Un estudio revela que la obesidad deja huellas en el ADN infantil m\u00e1s all\u00e1 de la propia gen\u00e9tica. Los resultados del trabajo, liderado por el Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), muestran que determinados cambios qu\u00edmicos en el ADN, conocidos como metilaci\u00f3n y relacionados con la regulaci\u00f3n de la actividad de los genes, permiten distinguir entre quienes mejoran, empeoran o mantienen estable su\u00a0resistencia a la insulina durante la pubertad.<\/p>\n

El equipo investigador ha identificado 120 regiones epigen\u00e9ticas asociadas a distintas trayectorias de resistencia a la insulina en ni\u00f1os y ni\u00f1as con obesidad<\/p>\n

El equipo investigador ha identificado 120 regiones epigen\u00e9ticas asociadas a distintas trayectorias de resistencia a la insulina en ni\u00f1os y ni\u00f1as con obesidad. Adem\u00e1s, muchas de estas se\u00f1ales no parecen depender \u00fanicamente de variantes gen\u00e9ticas heredadas, sino que podr\u00edan estar influenciadas por factores ambientales, el estilo de vida o el propio estado metab\u00f3lico asociado a la obesidad mantenida en el tiempo. Los detalles de la investigaci\u00f3n se publican en la revista Cardiovascular Diabetology.<\/p>\n

\u201cLa resistencia a la insulina en edades tempranas incrementa el riesgo futuro de desarrollar diabetes tipo 2 y enfermedad cardiovascular. Comprender c\u00f3mo evolucionan estas se\u00f1ales epigen\u00e9ticas durante la pubertad puede ayudar a identificar de forma precoz a los menores con mayor riesgo metab\u00f3lico\u201d, explican los coordinadores del estudio Concepci\u00f3n M. Aguilera Garc\u00eda, del \u00e1rea de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n del CIBER (CIBEROBN), Jes\u00fas Alcal\u00e1-Fdez, del Instituto Andaluz Interuniversitario en Data Science and Computational Intelligence (DaSCI) y Augusto Anguita, del Instituto de Salud Global de Barcelona (ISGlobal).<\/p>\n


\n \"Las
\n <\/a><\/p>\n

<\/a><\/p>\n

Las tasas de obesidad se ralentizan en pa\u00edses de ingresos altos, pero se aceleran en el resto<\/h3>\n

<\/p>\n


\n Yoana Kaloyanova
\n <\/a> <\/p>\n

<\/a><\/p>\n

Salud metab\u00f3lica desde la infancia<\/h2>\n

El equipo investigador combin\u00f3 an\u00e1lisis gen\u00e9ticos y epigen\u00e9ticos de alta resoluci\u00f3n para seguir c\u00f3mo estas se\u00f1ales evolucionaban desde la prepubertad hasta la adolescencia.<\/p>\n

Los resultados podr\u00edan contribuir en el futuro al desarrollo de biomarcadores tempranos y al dise\u00f1o de intervenciones preventivas m\u00e1s personalizadas<\/p>\n

Los hallazgos refuerzan la relaci\u00f3n entre el entorno, la obesidad y la salud metab\u00f3lica desde edades tempranas y suponen un avance hacia estrategias de medicina de precisi\u00f3n orientadas a detectar precozmente el riesgo cardiometab\u00f3lico e intervenir antes de que aparezcan alteraciones metab\u00f3licas m\u00e1s graves.<\/p>\n

En este sentido, los resultados podr\u00edan contribuir en el futuro al desarrollo de biomarcadores tempranos y al dise\u00f1o de intervenciones preventivas m\u00e1s personalizadas frente a enfermedades como la diabetes tipo 2 o las patolog\u00edas cardiovasculares.<\/p>\n

El trabajo est\u00e1 enmarcado dentro del proyecto europeo EprObes sobre prevenci\u00f3n de la obesidad infantil, financiado por el Instituto de Salud Carlos III (ISCIII) a trav\u00e9s del proyecto EXOMAIR. El estudio ha sido coliderado por la Universidad de Granada (UGR), en colaboraci\u00f3n con el Instituto de Salud Global de Barcelona (ISGlobal), centro impulsado por Fundaci\u00f3n \u201dla Caixa\u201d.<\/p>\n

Referencia:<\/p>\n

Anguita-Ruiz, A., Torres-Martos, \u00c1., Bustos-Aibar, M., Set\u00f3-Llorens, A., Ruiz-Ojeda, F. J., Moreno, L. A., Gil, \u00c1., Gil-Campos, M., Bueno, G., Leis, R., Alcal\u00e1-Fdez, J., & Aguilera, C. M. (2026). Novel epigenetic marks of insulin resistance trajectories in a longitudinal study of childhood obesity. Cardiovascular Diabetology<\/a> (2026).<\/p>","protected":false},"excerpt":{"rendered":"

Un estudio revela que la obesidad deja huellas en el ADN infantil m\u00e1s all\u00e1 de la propia gen\u00e9tica. Los resultados del trabajo, liderado por el Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), muestran que determinados cambios qu\u00edmicos en el ADN, conocidos como metilaci\u00f3n y relacionados con la regulaci\u00f3n de la actividad de los genes, permiten […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-204897","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nLa obesidad deja huellas epigen\u00e9ticas en el ADN de los ni\u00f1os - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/la-obesidad-deja-huellas-epigeneticas-en-el-adn-de-los-ninos\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La obesidad deja huellas epigen\u00e9ticas en el ADN de los ni\u00f1os\" \/>\n<meta property=\"og:description\" content=\"Un estudio revela que la obesidad deja huellas en el ADN infantil m\u00e1s all\u00e1 de la propia gen\u00e9tica. 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