{"id":206362,"date":"2026-07-02T10:28:05","date_gmt":"2026-07-02T09:28:05","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/la-identificacion-de-nuevas-claves-moleculares-del-mieloma-multiple-permite-terapias-mas-precisas\/"},"modified":"2026-07-02T10:28:05","modified_gmt":"2026-07-02T09:28:05","slug":"la-identificacion-de-nuevas-claves-moleculares-del-mieloma-multiple-permite-terapias-mas-precisas","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/la-identificacion-de-nuevas-claves-moleculares-del-mieloma-multiple-permite-terapias-mas-precisas\/","title":{"rendered":"La identificaci\u00f3n de nuevas claves moleculares del mieloma m\u00faltiple permite terapias m\u00e1s precisas"},"content":{"rendered":"

Un equipo de investigaci\u00f3n del Cima y de la Cl\u00ednica Universidad de Navarra han identificado nuevas claves moleculares del mieloma m\u00faltiple. Este tipo de c\u00e1ncer hematol\u00f3gico que afecta a la m\u00e9dula \u00f3sea se caracteriza por su resistencia a los tratamientos, lo que provoca reca\u00eddas en los pacientes.\u00a0<\/p>\n

El estudio se ha centrado en analizar qu\u00e9 factores de transcripci\u00f3n (prote\u00ednas clave que regulan la activaci\u00f3n de genes) son esenciales en el desarrollo del mieloma m\u00faltiple. Esta investigaci\u00f3n, integrada en el Cancer Center Cl\u00ednica Universidad de Navarra, se basa en trabajos anteriores que estudiaron el epigenoma completo del mieloma.\u00a0<\/p>\n

<\/p>\n

El papel de IRF2, un factor de transcripci\u00f3n cuyo papel en esta enfermedad no se conoc\u00eda hasta ahora y que puede convertirse en una buena diana terap\u00e9utica<\/p>\n

Nahia G\u00f3mez-Echarte, primera autora
\n<\/p>\n

\u201cEn ellos, desciframos que los factores de transcripci\u00f3n podr\u00edan desempe\u00f1ar un papel clave en las alteraciones epigen\u00f3micas del mieloma m\u00faltiple. En el trabajo que acabamos de publicar demostramos el papel de IRF2, un factor de transcripci\u00f3n cuyo papel en esta enfermedad no se conoc\u00eda hasta ahora y que puede convertirse en una buena diana terap\u00e9utica\u201d, explica Nahia G\u00f3mez-Echarte, investigadora postdoctoral del Cima y primera autora del trabajo, cuyos resultados se acaban de publicar en el \u00faltimo n\u00famero de la revista cient\u00edfica Blood.<\/p>\n

\u201cAsimismo, hemos confirmado que su expresi\u00f3n es un buen biomarcador, porque nos permite estratificar a los pacientes con mejor o peor pron\u00f3stico\u201d, se\u00f1ala Xabier Agirre, investigador principal del Grupo de Epigen\u00e9tica del Cima y codirector del trabajo, junto con los doctores Felipe Pr\u00f3sper y Edurne San Jos\u00e9-En\u00e9riz.<\/p>\n


\n \"Una
\n <\/a><\/p>\n

<\/a><\/p>\n

Una nueva inmunoterapia contra el mieloma m\u00faltiple es m\u00e1s efectiva que la CAR-T<\/h3>\n

<\/p>\n


\n SINC
\n <\/a> <\/p>\n

<\/a><\/p>\n

Predecir lar respuesta al tratamiento<\/h2>\n

La investigaci\u00f3n ha analizado 230 factores de transcripci\u00f3n detectados mediante herramientas computacionales. Posteriormente, se seleccionaron 54 factores que s\u00ed estaban expresados en c\u00e9lulas de mieloma.<\/p>\n

Para cada uno de esos factores de transcripci\u00f3n se dise\u00f1aron 10 gu\u00edas CRISPR diferentes, con el objetivo de ver si la inhibici\u00f3n de esos factores era clave para la viabilidad de las c\u00e9lulas de mieloma. En este an\u00e1lisis se identificaron 22 factores potencialmente esenciales para el desarrollo de este tipo de c\u00e1ncer.<\/p>\n

<\/p>\n

Incorporar este biomarcador a los sistemas actuales de clasificaci\u00f3n del mieloma m\u00faltiple podr\u00eda mejorar la capacidad para predecir la respuesta de los pacientes a los tratamientos<\/p>\n

Xabier Agirre, investigador principal (Grupo de Epigen\u00e9tica del Cima)
\n<\/p>\n

Entre estos factores de transcripci\u00f3n, los cient\u00edficos del Cima han demostrado que IRF2 desempe\u00f1a funciones biol\u00f3gicas claves, como es la regulaci\u00f3n de la necroptosis (un tipo de muerte celular), la migraci\u00f3n y el control del ciclo celular en el mieloma m\u00faltiple.<\/p>\n

Adem\u00e1s, el estudio revela que los niveles de expresi\u00f3n de IRF2 permiten estratificar mejor a los pacientes, diferenciando aquellos con mejor o peor pron\u00f3stico.\u00a0<\/p>\n

\u201cIncorporar este biomarcador a los sistemas actuales de clasificaci\u00f3n del mieloma m\u00faltiple podr\u00eda mejorar la capacidad para predecir la respuesta de los pacientes a los tratamientos\u201d, apunta Agirre.<\/p>\n

El trabajo, realizado en el marco del CIBER de C\u00e1ncer (CIBERONC), ha contado con financiaci\u00f3n p\u00fablica del Instituto de Salud Carlos III y del Gobierno de Navarra, as\u00ed como con el apoyo de instituciones privadas como la Fundaci\u00f3n Paula and Rodger Riney.<\/p>\n

Referencia:<\/p>\n

G\u00f3mez-Echarte, N. et al. \u201cIRF2 is an Essential Transcription Factor with Pathogenic and Prognostic Impact in Multiple Myeloma\u201d. Blood<\/a> (2026).<\/p>","protected":false},"excerpt":{"rendered":"

Un equipo de investigaci\u00f3n del Cima y de la Cl\u00ednica Universidad de Navarra han identificado nuevas claves moleculares del mieloma m\u00faltiple. Este tipo de c\u00e1ncer hematol\u00f3gico que afecta a la m\u00e9dula \u00f3sea se caracteriza por su resistencia a los tratamientos, lo que provoca reca\u00eddas en los pacientes.\u00a0 El estudio se ha centrado en analizar qu\u00e9 […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-206362","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nLa identificaci\u00f3n de nuevas claves moleculares del mieloma m\u00faltiple permite terapias m\u00e1s precisas - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/la-identificacion-de-nuevas-claves-moleculares-del-mieloma-multiple-permite-terapias-mas-precisas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La identificaci\u00f3n de nuevas claves moleculares del mieloma m\u00faltiple permite terapias m\u00e1s precisas\" \/>\n<meta property=\"og:description\" content=\"Un equipo de investigaci\u00f3n del Cima y de la Cl\u00ednica Universidad de Navarra han identificado nuevas claves moleculares del mieloma m\u00faltiple. 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