{"id":206720,"date":"2026-07-08T13:27:59","date_gmt":"2026-07-08T12:27:59","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/identifican-un-mecanismo-clave-que-regula-el-uso-de-la-grasa-como-fuente-de-energia\/"},"modified":"2026-07-08T13:27:59","modified_gmt":"2026-07-08T12:27:59","slug":"identifican-un-mecanismo-clave-que-regula-el-uso-de-la-grasa-como-fuente-de-energia","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/identifican-un-mecanismo-clave-que-regula-el-uso-de-la-grasa-como-fuente-de-energia\/","title":{"rendered":"Identifican un mecanismo clave que regula el uso de la grasa como fuente de energ\u00eda"},"content":{"rendered":"

Un estudio del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) ha identificado un mecanismo que regula c\u00f3mo el organismo utiliza la grasa almacenada para producir energ\u00eda.\u00a0<\/p>\n

Los resultados, que se publican en The EMBO Journal, muestran que el calcio presente en el interior de las mitocondrias act\u00faa como una se\u00f1al que determina si estos org\u00e1nulos permanecen unidos o se separan de las gotas lip\u00eddicas, donde las c\u00e9lulas almacenan la grasa.\u00a0<\/p>\n

Las mitocondrias son las estructuras celulares encargadas de generar la mayor parte de la energ\u00eda necesaria para el funcionamiento de los tejidos<\/p>\n

Las mitocondrias son las estructuras celulares encargadas de generar la mayor parte de la energ\u00eda necesaria para el funcionamiento de los tejidos. En el tejido adiposo marr\u00f3n, un tipo de grasa especializada en la producci\u00f3n de calor y el gasto energ\u00e9tico, una parte de las mitocondrias permanece asociada a las gotas lip\u00eddicas, lo que forma las denominadas mitocondrias peridropletales. Estas mitocondrias desempe\u00f1an un papel esencial en la gesti\u00f3n de las reservas energ\u00e9ticas celulares.\u00a0<\/p>\n

Seg\u00fan la primera autora del trabajo e investigadora del centro espa\u00f1ol, Rebeca Ac\u00edn-P\u00e9rez, el aumento de los niveles de calcio en el interior de las mitocondrias provoca cambios en su morfolog\u00eda y favorece su separaci\u00f3n de las gotas lip\u00eddicas. \u201cEste proceso resulta esencial para que las enzimas responsables de la degradaci\u00f3n de las grasas, conocidas como lipasas, puedan acceder a los l\u00edpidos almacenados y convertirlos en energ\u00eda\u201d, asegura la investigadora.<\/p>\n


\n \"Un
\n <\/a><\/p>\n

<\/a><\/p>\n

Un defecto en el transporte de grasas revela la causa de las raras crisis metab\u00f3licas infantiles<\/h3>\n

<\/p>\n


\n SINC
\n <\/a> <\/p>\n

<\/a><\/p>\n

Un actor que moviliza las grasas<\/h2>\n

Los autores del estudio observaron que esta separaci\u00f3n de las mitocondrias se produce antes del inicio de la lip\u00f3lisis al actuar como una especie de interruptor molecular que pone en marcha la movilizaci\u00f3n de las reservas grasas.\u00a0<\/p>\n

En concreto, el intercambiador mitocondrial de calcio NCLX controla la salida de calcio desde las mitocondrias. Cuando la actividad de NCLX disminuye, aumenta la acumulaci\u00f3n de calcio mitocondrial, se favorece la separaci\u00f3n de las mitocondrias de las gotas lip\u00eddicas y se incrementa la utilizaci\u00f3n de grasa como fuente de energ\u00eda.\u00a0<\/p>\n

Esta separaci\u00f3n de las mitocondrias se produce antes del inicio de la lip\u00f3lisis<\/p>\n

Por el contrario, cuando NCLX est\u00e1 activo, las mitocondrias tienden a permanecer asociadas a las reservas lip\u00eddicas. Los investigadores tambi\u00e9n identificaron una funci\u00f3n relevante para la fosfodiesterasa PDE2A, una prote\u00edna que regula indirectamente este sistema al modular los niveles intracelulares de calcio.\u00a0<\/p>\n

M\u00e1s all\u00e1 de describir este mecanismo biol\u00f3gico, el trabajo expone que su manipulaci\u00f3n farmacol\u00f3gica puede tener importantes consecuencias metab\u00f3licas. En modelos animales de obesidad, la inhibici\u00f3n de PDE2A increment\u00f3 la asociaci\u00f3n entre mitocondrias y gotas lip\u00eddicas, redujo la degradaci\u00f3n de grasa y favoreci\u00f3 el uso de glucosa como combustible energ\u00e9tico. Este cambio metab\u00f3lico se asoci\u00f3 con una mejora del control energ\u00e9tico y un aumento del gasto metab\u00f3lico.\u00a0<\/p>\n

En conjunto, los resultados revelan que la interacci\u00f3n entre las mitocondrias y las gotas lip\u00eddicas es un proceso din\u00e1mico y finamente regulado por se\u00f1ales intracelulares como el calcio. \u201cComprender c\u00f3mo se controla esta relaci\u00f3n proporciona una nueva perspectiva sobre los mecanismos que regulan el metabolismo energ\u00e9tico y abre posibles v\u00edas para el desarrollo de estrategias terap\u00e9uticas frente a la obesidad y otras enfermedades metab\u00f3licas\u201d, se\u00f1alan los autores.\u00a0<\/p>\n

Referencia:<\/p>\n

Ac\u00edn – Perez. et al. Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets.\u00a0The EMBO Journal<\/a> 2026.<\/p>","protected":false},"excerpt":{"rendered":"

Un estudio del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) ha identificado un mecanismo que regula c\u00f3mo el organismo utiliza la grasa almacenada para producir energ\u00eda.\u00a0 Los resultados, que se publican en The EMBO Journal, muestran que el calcio presente en el interior de las mitocondrias act\u00faa como una se\u00f1al que determina si estos […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-206720","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nIdentifican un mecanismo clave que regula el uso de la grasa como fuente de energ\u00eda - 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