{"id":207140,"date":"2026-07-22T10:28:27","date_gmt":"2026-07-22T09:28:27","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/un-mapa-virtual-reconstruye-como-se-forma-el-corazon-de-los-mamiferos\/"},"modified":"2026-07-22T10:28:27","modified_gmt":"2026-07-22T09:28:27","slug":"un-mapa-virtual-reconstruye-como-se-forma-el-corazon-de-los-mamiferos","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/un-mapa-virtual-reconstruye-como-se-forma-el-corazon-de-los-mamiferos\/","title":{"rendered":"Un mapa virtual reconstruye c\u00f3mo se forma el coraz\u00f3n de los mam\u00edferos"},"content":{"rendered":"

El coraz\u00f3n es el primer \u00f3rgano que se forma y comienza a funcionar en los mam\u00edferos. Durante el desarrollo embrionario, un grupo plano de c\u00e9lulas precursoras, denominado\u00a0primordio card\u00edaco, se desplaza y cambia de forma hasta convertirse en un tubo tridimensional capaz de bombear sangre.<\/p>\n

Un equipo del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) ha desarrollado una herramienta que permite analizar este proceso de forma cuantitativa. El estudio, publicado en eLife, combina la microscop\u00eda en directo de modelos experimentales con t\u00e9cnicas avanzadas de an\u00e1lisis de im\u00e1genes y aprendizaje autom\u00e1tico.<\/p>\n

Comprender estas primeras etapas puede ayudar a explicar c\u00f3mo se desarrolla normalmente el coraz\u00f3n y de qu\u00e9 manera algunas alteraciones pueden dar lugar a cardiopat\u00edas cong\u00e9nitas. Su estudio resulta complejo porque el tejido cambia r\u00e1pidamente de forma al mismo tiempo que el coraz\u00f3n embrionario empieza a latir.<\/p>\n

<\/p>\n

Nuestro mapa virtual permite ahora seguir c\u00f3mo cada regi\u00f3n del tejido card\u00edaco inicial contribuye al tubo card\u00edaco primitivo<\/p>\n

Morena Raiola (CNIC)
\n<\/p>\n

\u201cLa microscop\u00eda en directo nos permite observar el desarrollo del coraz\u00f3n, pero convertir estas im\u00e1genes complejas en informaci\u00f3n cuantitativa ha supuesto un gran reto. Nuestro mapa virtual permite ahora seguir c\u00f3mo cada regi\u00f3n del tejido card\u00edaco inicial contribuye al tubo card\u00edaco primitivo\u201d, explica Morena Raiola, primera autora del estudio e investigadora del CNIC.<\/p>\n


\n \"Hallan
\n <\/a><\/p>\n

<\/a><\/p>\n

Hallan un mayor nivel de micropl\u00e1sticos en el coraz\u00f3n de pacientes infartados<\/h3>\n

<\/p>\n


\n Marcos D. Oliveros
\n <\/a> <\/p>\n

<\/a><\/p>\n

Seguir el tejido<\/h2>\n

El equipo desarroll\u00f3 un m\u00e9todo computacional para rastrear el movimiento de los tejidos a partir de im\u00e1genes de microscop\u00eda tomadas a lo largo del tiempo. Para comprobar su precisi\u00f3n, compar\u00f3 sus resultados con los desplazamientos de c\u00e9lulas individuales cuyo seguimiento se hab\u00eda realizado de forma experimental.<\/p>\n

Los investigadores recurrieron despu\u00e9s al aprendizaje autom\u00e1tico para alinear los datos de distintos embriones y reunirlos en un \u00fanico modelo del desarrollo card\u00edaco. La reconstrucci\u00f3n muestra d\u00f3nde y cu\u00e1ndo el tejido se estira, crece o modifica la direcci\u00f3n de su movimiento durante la transformaci\u00f3n del primordio card\u00edaco en el tubo card\u00edaco lineal.<\/p>\n

La herramienta permite seguir la trayectoria de cualquier punto del tejido inicial y predecir d\u00f3nde se situar\u00e1 en el tubo card\u00edaco primitivo<\/p>\n

Uno de los principales resultados es un mapa virtual de destino que permite seguir la trayectoria de cualquier punto del tejido inicial y predecir d\u00f3nde se situar\u00e1 en el tubo card\u00edaco primitivo. De este modo, relaciona la posici\u00f3n inicial de una c\u00e9lula o regi\u00f3n con la parte del futuro coraz\u00f3n a la que contribuir\u00e1.<\/p>\n

El an\u00e1lisis muestra que las c\u00e9lulas vecinas suelen desplazarse juntas, aunque no todas las zonas se deforman del mismo modo. El primordio card\u00edaco se divide en regiones diferenciadas, cada una con su propio patr\u00f3n de movimiento y crecimiento. La coordinaci\u00f3n entre estos comportamientos transforma una estructura inicialmente plana y bilateral en un tubo tridimensional de orientaci\u00f3n longitudinal.<\/p>\n

<\/p>\n

Podemos describir la formaci\u00f3n del tubo card\u00edaco de forma cuantitativa y demostrar que el coraz\u00f3n primitivo se forma a partir de regiones de tejido con patrones de deformaci\u00f3n espec\u00edficos, pero coordinados con precisi\u00f3n<\/p>\n

Miguel Torres (CNIC)
\n<\/p>\n

\u201cEl principal avance es que ahora podemos describir la formaci\u00f3n del tubo card\u00edaco de forma cuantitativa y demostrar que el coraz\u00f3n primitivo se forma a partir de distintas regiones de tejido que siguen patrones de deformaci\u00f3n espec\u00edficos, pero coordinados con precisi\u00f3n\u201d, se\u00f1ala Miguel Torres, jefe del Grupo de Control Gen\u00e9tico del Desarrollo y Regeneraci\u00f3n de \u00d3rganos del CNIC y autor principal del trabajo.<\/p>\n

<\/a><\/p>\n

La forma del ventr\u00edculo<\/h2>\n

El estudio tambi\u00e9n aporta informaci\u00f3n sobre la formaci\u00f3n de la c\u00e1mara ventricular primitiva. En la zona destinada a convertirse en la curva externa del tubo card\u00edaco, el tejido se expande hasta adquirir una forma semejante a medio barril.<\/p>\n

El m\u00e9todo tambi\u00e9n podr\u00eda aplicarse al estudio de otros \u00f3rganos y tejidos, as\u00ed como a la investigaci\u00f3n de cardiopat\u00edas cong\u00e9nitas y al desarrollo de estrategias de ingenier\u00eda tisular<\/p>\n

Dos regiones con forma de cintur\u00f3n, situadas en los polos arterial y venoso, limitan esta expansi\u00f3n en ambos extremos. Seg\u00fan los autores, estas zonas gu\u00edan el crecimiento del tejido y contribuyen a conferir al ventr\u00edculo en desarrollo su forma caracter\u00edstica.<\/p>\n

El m\u00e9todo podr\u00eda aplicarse al estudio de otros \u00f3rganos y tejidos que atraviesan transformaciones tridimensionales complejas durante el desarrollo embrionario. A largo plazo, los conocimientos obtenidos podr\u00edan servir de base para investigar las cardiopat\u00edas cong\u00e9nitas y desarrollar estrategias de ingenier\u00eda tisular.<\/p>\n

Referencia:<\/p>\n

Morena Raiola et al \u201cQuantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation\u201d. \u00a0eLife<\/a>, 2026<\/p>","protected":false},"excerpt":{"rendered":"

El coraz\u00f3n es el primer \u00f3rgano que se forma y comienza a funcionar en los mam\u00edferos. Durante el desarrollo embrionario, un grupo plano de c\u00e9lulas precursoras, denominado\u00a0primordio card\u00edaco, se desplaza y cambia de forma hasta convertirse en un tubo tridimensional capaz de bombear sangre. Un equipo del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-207140","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nUn mapa virtual reconstruye c\u00f3mo se forma el coraz\u00f3n de los mam\u00edferos - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/un-mapa-virtual-reconstruye-como-se-forma-el-corazon-de-los-mamiferos\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un mapa virtual reconstruye c\u00f3mo se forma el coraz\u00f3n de los mam\u00edferos\" \/>\n<meta property=\"og:description\" content=\"El coraz\u00f3n es el primer \u00f3rgano que se forma y comienza a funcionar en los mam\u00edferos. Durante el desarrollo embrionario, un grupo plano de c\u00e9lulas precursoras, denominado\u00a0primordio card\u00edaco, se desplaza y cambia de forma hasta convertirse en un tubo tridimensional capaz de bombear sangre. 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