{"id":207353,"date":"2026-07-30T11:28:18","date_gmt":"2026-07-30T10:28:18","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/identifican-una-proteina-clave-para-proteger-el-foliculo-piloso-de-la-perdida-de-pelo\/"},"modified":"2026-07-30T11:28:18","modified_gmt":"2026-07-30T10:28:18","slug":"identifican-una-proteina-clave-para-proteger-el-foliculo-piloso-de-la-perdida-de-pelo","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/identifican-una-proteina-clave-para-proteger-el-foliculo-piloso-de-la-perdida-de-pelo\/","title":{"rendered":"Identifican una prote\u00edna clave para proteger el fol\u00edculo piloso de la p\u00e9rdida de pelo"},"content":{"rendered":"

El fol\u00edculo piloso es un peque\u00f1o \u00f3rgano de la piel con una gran capacidad para renovarse durante toda la vida. Para ello, alterna fases de crecimiento, regresi\u00f3n y reposo. Este ciclo depende de la comunicaci\u00f3n entre las c\u00e9lulas madre del fol\u00edculo, el entorno que las rodea, conocido como\u00a0\u2018nicho\u2019, y la papila d\u00e9rmica, una estructura situada en la base del fol\u00edculo esencial para iniciar cada nuevo ciclo de crecimiento.<\/p>\n

GRK2 act\u00faa como un regulador del equilibrio del fol\u00edculo piloso. Cuando falta esta prote\u00edna, el fol\u00edculo pierde la capacidad de responder a las se\u00f1ales que normalmente coordinan el crecimiento del pelo<\/p>\n

Un equipo de investigaci\u00f3n liderado por\u00a0Federico Mayor y Catalina Ribas en el Centro de Biolog\u00eda Molecular Severo Ochoa (centro mixto de la Universidad Aut\u00f3noma de Madrid y el CSIC) y el IIS-Princesa ha identificado una funci\u00f3n desconocida de la prote\u00edna se\u00f1alizadora GRK2, clave para mantener este equilibrio.<\/p>\n

El trabajo, publicado en Journal of Investigative Dermatology, demuestra que la ausencia de esta prote\u00edna altera el ciclo normal del pelo, favorece la aparici\u00f3n de quistes asociados al fol\u00edculo y conduce progresivamente a la p\u00e9rdida de pelo en modelos de rat\u00f3n.<\/p>\n

\u201cNuestros resultados indican que GRK2 act\u00faa como un regulador central del equilibrio fisiol\u00f3gico del fol\u00edculo piloso. Cuando falta esta prote\u00edna, el fol\u00edculo pierde la capacidad de responder de forma adecuada a las se\u00f1ales que normalmente coordinan el crecimiento del pelo\u201d, explican los autores del estudio.<\/p>\n

<\/a><\/p>\n

Un fallo en la comunicaci\u00f3n celular<\/h2>\n

El trabajo muestra que la ausencia de GRK2 altera varios mecanismos de comunicaci\u00f3n celular esenciales para activar el crecimiento del pelo. Como consecuencia, algunos fol\u00edculos no progresan correctamente durante esta fase y generan estructuras qu\u00edsticas que quedan desacopladas del ciclo normal del pelo.<\/p>\n

Una de las principales aportaciones del estudio es desvelar c\u00f3mo estas estructuras qu\u00edsticas pueden contribuir a la p\u00e9rdida progresiva de pelo. Los quistes desplazan la papila d\u00e9rmica lejos del nicho de c\u00e9lulas madre del fol\u00edculo e interrumpen una comunicaci\u00f3n esencial para iniciar nuevos ciclos de crecimiento. Con el tiempo, esta alteraci\u00f3n da\u00f1a la arquitectura del nicho, extingue las c\u00e9lulas madre foliculares y compromete la regeneraci\u00f3n del pelo.<\/p>\n


\n \"Basta
\n <\/a><\/p>\n

<\/a><\/p>\n

Basta de tomaduras de pelo: qu\u00e9 funciona y qu\u00e9 no contra la calvicie<\/h3>\n

<\/p>\n

Sergio Ferrer<\/p>\n

\u201cLo m\u00e1s relevante es que no solo observamos una alteraci\u00f3n morfol\u00f3gica, sino que hemos podido conectar esa alteraci\u00f3n con un mecanismo de p\u00e9rdida de funci\u00f3n del fol\u00edculo. Los quistes acaban actuando como barreras que separan f\u00edsicamente a las c\u00e9lulas madre de las se\u00f1ales que necesitan para mantener el ciclo del pelo\u201d, se\u00f1alan los autores.<\/p>\n

<\/a><\/p>\n

Claves para entender la alopecia<\/h2>\n

Adem\u00e1s, el trabajo muestra que estas estructuras qu\u00edsticas presentan cambios en la identidad de sus c\u00e9lulas y son infiltradas por c\u00e9lulas inmunitarias durante el envejecimiento. Este proceso comparte algunas caracter\u00edsticas con mecanismos descritos en personas con alopecias inmunomediadas, como la alopecia areata.<\/p>\n

Aunque los resultados se han obtenido en ratones y no implican todav\u00eda una aplicaci\u00f3n cl\u00ednica directa, aportan una nueva perspectiva sobre los mecanismos que mantienen la salud del fol\u00edculo piloso y ayudan a explicar c\u00f3mo distintas alteraciones pueden desembocar en la p\u00e9rdida de pelo.<\/p>\n

Aunque los resultados se han obtenido en ratones, aportan una nueva perspectiva sobre los mecanismos que mantienen la salud del fol\u00edculo piloso<\/p>\n

\u201cEste estudio abre nuevas preguntas sobre c\u00f3mo la p\u00e9rdida de identidad celular, la inflamaci\u00f3n y la comunicaci\u00f3n defectuosa dentro del fol\u00edculo pueden contribuir a distintos tipos de alopecia. Comprender estos mecanismos b\u00e1sicos es un paso necesario para explorar futuras estrategias terap\u00e9uticas\u201d, concluyen los autores.<\/p>\n

El trabajo ha contado tambi\u00e9n con la participaci\u00f3n de investigadores del CIEMAT y de la Universidad de Southampton (Reino Unido).<\/p>\n

Referencia<\/p>\n

Alejandro Asensio, Maria Sanz-Flores et al.\u00a0\u201cThe G-Protein-Coupled Receptor Kinase 2 Orchestrates Hair Follicle Homeostasis\u201d.\u00a0Journal of Investigative Dermatology<\/a> (2026)\u00a0<\/p>","protected":false},"excerpt":{"rendered":"

El fol\u00edculo piloso es un peque\u00f1o \u00f3rgano de la piel con una gran capacidad para renovarse durante toda la vida. Para ello, alterna fases de crecimiento, regresi\u00f3n y reposo. Este ciclo depende de la comunicaci\u00f3n entre las c\u00e9lulas madre del fol\u00edculo, el entorno que las rodea, conocido como\u00a0\u2018nicho\u2019, y la papila d\u00e9rmica, una estructura situada […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-207353","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nIdentifican una prote\u00edna clave para proteger el fol\u00edculo piloso de la p\u00e9rdida de pelo - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/identifican-una-proteina-clave-para-proteger-el-foliculo-piloso-de-la-perdida-de-pelo\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifican una prote\u00edna clave para proteger el fol\u00edculo piloso de la p\u00e9rdida de pelo\" \/>\n<meta property=\"og:description\" content=\"El fol\u00edculo piloso es un peque\u00f1o \u00f3rgano de la piel con una gran capacidad para renovarse durante toda la vida. 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Para ello, alterna fases de crecimiento, regresi\u00f3n y reposo. 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