{"id":207605,"date":"2026-08-06T12:28:19","date_gmt":"2026-08-06T11:28:19","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/un-farmaco-usa-la-glucosa-para-frenar-la-expansion-del-cancer-en-ratones\/"},"modified":"2026-08-06T12:28:19","modified_gmt":"2026-08-06T11:28:19","slug":"un-farmaco-usa-la-glucosa-para-frenar-la-expansion-del-cancer-en-ratones","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/un-farmaco-usa-la-glucosa-para-frenar-la-expansion-del-cancer-en-ratones\/","title":{"rendered":"Un f\u00e1rmaco usa la glucosa para frenar la expansi\u00f3n del c\u00e1ncer en ratones"},"content":{"rendered":"

Las c\u00e9lulas cancerosas utilizan la glucosa para crecer, por lo que muchos cient\u00edficos han intentado desarrollar tratamientos para cortarles el suministro. Un f\u00e1rmaco experimental, descrito en Nature Chemical Biology, las \u2018enga\u00f1a\u2019 para que consuman esta sustancia, a la vez que bloquea su fuente energ\u00e9tica de reserva: la grasa.<\/p>\n

Este compuesto somete a las c\u00e9lulas cancerosas a un estr\u00e9s tan intenso que muchas de ellas mueren<\/p>\n

Investigadores de la Universidad de Austin (Texas) se\u00f1alan que, al actuar sobre ambas fuentes a la vez, este compuesto somete a las c\u00e9lulas cancerosas a un estr\u00e9s tan intenso que muchas de ellas mueren. Los resultados demostraron su eficacia en una forma agresiva de melanoma en ratones.<\/p>\n

\u201cMe gusta pensar en esta tecnolog\u00eda como un drag\u00f3n de dos cabezas\u201d, afirma la col\u00edder del trabajo e investigadora de la instituci\u00f3n estadounidense, Xiaolu Lim Ang Cambronne. \u201cEstamos acelerando al m\u00e1ximo una parte de la c\u00e9lula mientras que, al mismo tiempo, debilitamos a otra\u00bb. Parece ser extremadamente eficaz\u201d, expresa.<\/p>\n


\n \"El
\n <\/a><\/p>\n

<\/a><\/p>\n

El col\u00e1geno se organiza como un condensado l\u00edquido en el interior celular<\/h3>\n

<\/p>\n


\n SINC
\n <\/a> <\/p>\n

<\/a><\/p>\n

Doble acci\u00f3n<\/h2>\n

Durante los experimentos, el f\u00e1rmaco result\u00f3 \u00fatil contra varios tipos de c\u00e9lulas humanas de distintos tipos de c\u00e1ncer o cultivos celulares, entre ellas las del melanoma, la leucemia, el c\u00e1ncer de mama, el c\u00e1ncer de pulm\u00f3n, el de h\u00edgado y el neuroblastoma.<\/p>\n

Una mol\u00e9cula denominada XJ-4-85 act\u00faa sobre la enzima responsable de acelerar la descomposici\u00f3n de la glucosa en el interior de las c\u00e9lulas y, despu\u00e9s, libera un compuesto que act\u00faa sobre la enzima CPT2, clave para obtener energ\u00eda a partir de los \u00e1cidos grasos en las mitocondrias. Al alterar simult\u00e1neamente ambas v\u00edas metab\u00f3licas, el tratamiento frena el crecimiento del tumor.<\/p>\n

El compuesto fue eficaz frente a c\u00e9lulas humanas de melanoma, leucemia y otros tipos de c\u00e1ncer<\/p>\n

\u201cEl modo en el que act\u00faa este f\u00e1rmaco fue totalmente inesperado\u201d, afirma el col\u00edder del trabajo e investigador del Laboratorio Hsu (EE.UU), Ken Hsu,\u00a0que dise\u00f1\u00f3 la mol\u00e9cula. \u201cSe necesit\u00f3 mucha investigaci\u00f3n para averiguar qu\u00e9 estaba pasando a nivel molecular. Tambi\u00e9n, nos sorprendi\u00f3 ver con qu\u00e9 selectividad se une a las c\u00e9lulas cancerosas\u201d.<\/p>\n

<\/a><\/p>\n

M\u00e1s all\u00e1 del c\u00e1ncer<\/h2>\n

Los f\u00e1rmacos que atacan el c\u00e1ncer a nivel molecular no son totalmente nuevos. Existe una clase de compuestos que utilizan un anticuerpo para dirigirse a las c\u00e9lulas tumorales y liberar una\u00a0carga de quimioterapia directamente en el tumor. No obstante, presentan numerosas limitaciones.<\/p>\n

Los expertos se\u00f1alan que se necesitan muchas m\u00e1s pruebas de laboratorio antes de que el f\u00e1rmaco pueda estudiarse en personas<\/p>\n

\u201cLos anticuerpos son dif\u00edciles de fabricar y, debido a su gran tama\u00f1o, solo pueden actuar sobre prote\u00ednas situadas en la superficie de las c\u00e9lulas cancerosas\u201d, explica Hsu. \u201cCreemos que este nuevo f\u00e1rmaco es equivalente, pero son m\u00e1s f\u00e1ciles de fabricar y, al ser m\u00e1s peque\u00f1os, pueden actuar sobre prote\u00ednas que se encuentran en el interior de las c\u00e9lulas\u201d.<\/p>\n

Esta investigaci\u00f3n se encuentra en sus primeras fases, aunque los resultados parecen prometedores. Los expertos se\u00f1alan que se necesitan muchas m\u00e1s pruebas de laboratorio antes de que el f\u00e1rmaco pueda estudiarse en personas. M\u00e1s all\u00e1, afirman que ilustra un nuevo enfoque para el dise\u00f1o de medicamentos de dos componentes, capaces de emplearse para otros tipo de enfermedades.\u00a0\u00a0<\/p>\n

Referencia:<\/p>\n

Jiang, X. A covalent PFKL activator suppresses tumor growth. Nature Chemical Biology<\/a>. 2026<\/p>","protected":false},"excerpt":{"rendered":"

Las c\u00e9lulas cancerosas utilizan la glucosa para crecer, por lo que muchos cient\u00edficos han intentado desarrollar tratamientos para cortarles el suministro. Un f\u00e1rmaco experimental, descrito en Nature Chemical Biology, las \u2018enga\u00f1a\u2019 para que consuman esta sustancia, a la vez que bloquea su fuente energ\u00e9tica de reserva: la grasa. Este compuesto somete a las c\u00e9lulas cancerosas […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-207605","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nUn f\u00e1rmaco usa la glucosa para frenar la expansi\u00f3n del c\u00e1ncer en ratones - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/un-farmaco-usa-la-glucosa-para-frenar-la-expansion-del-cancer-en-ratones\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un f\u00e1rmaco usa la glucosa para frenar la expansi\u00f3n del c\u00e1ncer en ratones\" \/>\n<meta property=\"og:description\" content=\"Las c\u00e9lulas cancerosas utilizan la glucosa para crecer, por lo que muchos cient\u00edficos han intentado desarrollar tratamientos para cortarles el suministro. 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