{"id":25719,"date":"2025-01-23T13:28:04","date_gmt":"2025-01-23T12:28:04","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/el-mayor-estudio-genetico-sobre-el-trastorno-bipolar-revela-nuevas-claves-de-la-enfermedad\/"},"modified":"2025-01-23T13:28:04","modified_gmt":"2025-01-23T12:28:04","slug":"el-mayor-estudio-genetico-sobre-el-trastorno-bipolar-revela-nuevas-claves-de-la-enfermedad","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/el-mayor-estudio-genetico-sobre-el-trastorno-bipolar-revela-nuevas-claves-de-la-enfermedad\/","title":{"rendered":"El mayor estudio gen\u00e9tico sobre el trastorno bipolar revela nuevas claves de la enfermedad"},"content":{"rendered":"

El Consorcio de Psiquiatr\u00eda Gen\u00f3mica, una red internacional de investigadores a la que pertenece Claudio Toma, del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM- CSIC-UAM), ha completado\u00a0el mayor estudio gen\u00e9tico realizado hasta la fecha sobre el trastorno bipolar.<\/p>\n

Este proyecto ha logrado avances fundamentales en la comprensi\u00f3n de esta enfermedad, que afecta a cerca de 50 millones de personas y es una de las principales causas de discapacidad a escala global.<\/p>\n

El trastorno bipolar\u00a0afecta a cerca de 50 millones de personas\u00a0y es una de las principales causas de discapacidad a escala global.<\/p>\n

Este trabajo, publicado en la revista\u00a0Nature<\/a>, representa un paso clave hacia la comprensi\u00f3n de las bases biol\u00f3gicas y gen\u00e9ticas del trastorno bipolar, lo que podr\u00eda abrir la puerta a futuros tratamientos personalizados y mejores estrategias de diagn\u00f3stico.<\/p>\n

<\/a><\/p>\n

Alta heredabilidad<\/h2>\n

A pesar de su alta heredabilidad (entre un 60 % y un 80 %), gran parte de los factores gen\u00e9ticos que originan el trastorno bipolar siguen siendo desconocidos. Este ambicioso estudio\u00a0ha analizado a m\u00e1s de 158.000 individuos\u00a0con trastorno bipolar y 2,8 millones de controles, incluyendo poblaciones europeas, asi\u00e1ticas, afroamericanas y latinas.<\/p>\n

\u201cEl an\u00e1lisis nos ha permitido\u00a0identificar 298 regiones gen\u00e9ticas asociadas con el trastorno, cuadruplicando los descubrimientos de estudios anteriores, y se han encontrado asociaciones gen\u00e9ticas espec\u00edficas en poblaciones asi\u00e1ticas orientales, lo que abre nuevas perspectivas para comprender c\u00f3mo var\u00eda el trastorno bipolar entre diferentes grupos \u00e9tnicos\u201d, indica Toma.<\/p>\n

<\/p>\n

El an\u00e1lisis nos ha permitido\u00a0identificar 298 regiones gen\u00e9ticas asociadas con el trastorno, cuadruplicando los descubrimientos de estudios anteriores<\/p>\n

Claudio Toma (CBM- CSIC-UAM)
\n
\n<\/a><\/p>\n

Diferencias gen\u00e9ticas entre los subtipos<\/h2>\n

Asimismo, se han identificado diferencias gen\u00e9ticas entre los subtipos de esta condici\u00f3n: el tipo I, caracterizado por episodios man\u00edacos graves, muestra mayor relaci\u00f3n gen\u00e9tica con la esquizofrenia, mientras que el tipo II, asociado a episodios depresivos frecuentes y menor man\u00eda, comparte mayor similitud gen\u00e9tica con la depresi\u00f3n mayor y el TDAH.<\/p>\n

El tipo I se asocia gen\u00e9ticamente con la esquizofrenia, mientras que el tipo II guarda mayor similitud gen\u00e9tica con la depresi\u00f3n mayor y el TDAH<\/p>\n

<\/a><\/p>\n

36 genes implicados<\/h2>\n

Un avance notable ha sido\u00a0la identificaci\u00f3n de 36 genes directamente implicados en la biolog\u00eda del trastorno bipolar. Algunos presentan variantes raras que alteran gravemente las prote\u00ednas de los individuos afectados, subrayando c\u00f3mo estas variantes gen\u00e9ticas comunes y raras convergen en el desarrollo de la enfermedad.<\/p>\n

El estudio tambi\u00e9n ha vinculado se\u00f1ales gen\u00e9ticas con tipos espec\u00edficos de c\u00e9lulas cerebrales, como las interneuronas GABA\u00e9rgicas y las neuronas espinosas medianas, y sorprendentemente, con c\u00e9lulas fuera del sistema nervioso central, como las del intestino y el p\u00e1ncreas.<\/p>\n

Estos hallazgos ampl\u00edan la perspectiva biol\u00f3gica del trastorno bipolar, ya que indican que\u00a0otros \u00f3rganos aparte del cerebro podr\u00edan desempe\u00f1ar un papel relevante\u00a0en su desarrollo.<\/p>","protected":false},"excerpt":{"rendered":"

El Consorcio de Psiquiatr\u00eda Gen\u00f3mica, una red internacional de investigadores a la que pertenece Claudio Toma, del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM- CSIC-UAM), ha completado\u00a0el mayor estudio gen\u00e9tico realizado hasta la fecha sobre el trastorno bipolar. Este proyecto ha logrado avances fundamentales en la comprensi\u00f3n de esta enfermedad, que afecta a cerca de […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-25719","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nEl mayor estudio gen\u00e9tico sobre el trastorno bipolar revela nuevas claves de la enfermedad - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/el-mayor-estudio-genetico-sobre-el-trastorno-bipolar-revela-nuevas-claves-de-la-enfermedad\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El mayor estudio gen\u00e9tico sobre el trastorno bipolar revela nuevas claves de la enfermedad\" \/>\n<meta property=\"og:description\" content=\"El Consorcio de Psiquiatr\u00eda Gen\u00f3mica, una red internacional de investigadores a la que pertenece Claudio Toma, del Centro de Biolog\u00eda Molecular Severo Ochoa (CBM- CSIC-UAM), ha completado\u00a0el mayor estudio gen\u00e9tico realizado hasta la fecha sobre el trastorno bipolar. 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