{"id":40711,"date":"2025-02-05T12:28:14","date_gmt":"2025-02-05T11:28:14","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/detectan-cambios-en-regiones-cerebrales-en-individuos-con-alzheimer-y-alta-carga-patologica\/"},"modified":"2025-02-05T12:28:14","modified_gmt":"2025-02-05T11:28:14","slug":"detectan-cambios-en-regiones-cerebrales-en-individuos-con-alzheimer-y-alta-carga-patologica","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/detectan-cambios-en-regiones-cerebrales-en-individuos-con-alzheimer-y-alta-carga-patologica\/","title":{"rendered":"Detectan cambios en regiones cerebrales en individuos con alzh\u00e9imer y alta carga patol\u00f3gica"},"content":{"rendered":"

Un equipo de investigaci\u00f3n liderado por la Universidad Complutense de Madrid ha identificado la asociaci\u00f3n entre la demanda de regiones cerebrales clave para facilitar y coordinar el flujo de informaci\u00f3n entre el resto de \u00e1reas y altos niveles de marcadores en sangre de patolog\u00eda de la enfermedad de Alzh\u00e9imer (EA) en individuos que a\u00fan no manifiestan deterioro cognitivo.<\/p>\n

Por estudios previos realizados en pacientes con deterioro cognitivo leve y demencia por EA, se sabe que las regiones con m\u00e1s flujo de informaci\u00f3n y, por lo tanto, m\u00e1s relevantes para distribuir y facilitar la comunicaci\u00f3n entre distintas \u00e1reas cerebrales terminan fallando y perdiendo su relevancia. Sin embargo, se desconoce qu\u00e9 pasa con esa especie de \u201ccentros de comunicaciones\u201d en etapas tempranas, cuando todav\u00eda no hay problemas cognitivos, pero s\u00ed comienza a haber patolog\u00eda subyacente<\/p>\n

El estudio, publicado en\u00a0Alzheimer’s Research & Therapy<\/a>, analiza c\u00f3mo cambiaba en personas cognitivamente sanas y distinta carga patol\u00f3gica la relaci\u00f3n entre la relevancia de distintas regiones y la prote\u00edna p-tau231, un marcador en sangre de patolog\u00eda.<\/p>\n

<\/p>\n

Solo entre individuos cognitivamente sanos, pero con niveles elevados de patolog\u00eda en sangre existe una asociaci\u00f3n<\/p>\n

Alejandra Garc\u00eda Colomo, UCM
\n<\/p>\n

\u201cSolo entre individuos cognitivamente sanos, pero con niveles elevados de patolog\u00eda en sangre existe una asociaci\u00f3n. Es decir, a partir de un cierto nivel de patolog\u00eda, las regiones m\u00e1s relevantes para controlar y distribuir el flujo de informaci\u00f3n empiezan a presentar cambios en cu\u00e1nta informaci\u00f3n reciben de otras regiones. As\u00ed, algunas de estas zonas muestran demandas excesivas en que se asocian a la patolog\u00eda incipiente y a un posterior colapso, mientras que otras experimentan p\u00e9rdidas de relevancia asociadas a disfunci\u00f3n neuronal\u201d, se\u00f1ala Alejandra Garc\u00eda Colomo, investigadora del Departamento de Psicolog\u00eda Experimental, Procesos Cognitivos y Logopedia de la UCM.<\/p>\n

<\/a><\/p>\n

Diagn\u00f3stico temprano del alzheimer<\/h2>\n

El estudio incluy\u00f3 a 104 participantes sin deterioro cognitivo, de los cuales 33 ten\u00edan niveles elevados de\u00a0prote\u00edna p-tau231 y cadenas ligeras de neurofilamentos (NfL), otro biomarcador, y 71 con una baja carga de patolog\u00eda. Se us\u00f3 la magnetoencefalograf\u00eda para medir la actividad cerebral y se analiz\u00f3 la centralidad de distintas regiones.<\/p>\n

Los resultados de este estudio pueden ser \u00fatiles para desarrollar herramientas de diagn\u00f3stico temprano del alzheimer y para evaluar tratamientos antes de que aparezcan los s\u00edntomas cl\u00ednicos.<\/p>\n

<\/p>\n

El estudio sugiere que los cambios en la funci\u00f3n cerebral y la organizaci\u00f3n del flujo de informaci\u00f3n comienzan mucho antes de que aparezcan los s\u00edntomas del alzheimer a la par que comienzan a elevarse algunos par\u00e1metros en sangre<\/p>\n

Alejandra Garc\u00eda Colomo
\n<\/p>\n

\u201cEl estudio sugiere que los cambios en la funci\u00f3n cerebral y la organizaci\u00f3n del flujo de informaci\u00f3n comienzan mucho antes de que aparezcan los s\u00edntomas del alzheimer a la par que comienzan a elevarse algunos par\u00e1metros en sangre\u201d, destaca la investigadora de la UCM.<\/p>\n

Esta informaci\u00f3n puede resultar de utilidad a los profesionales de la salud, investigadores y farmac\u00e9uticas para identificar a individuos en riesgo y monitorear la efectividad de intervenciones tempranas. \u201cAdem\u00e1s, el uso de biomarcadores en sangre y t\u00e9cnicas de imagen no invasivas facilita un acceso m\u00e1s amplio y menos costoso a herramientas de diagn\u00f3stico\u201d, a\u00f1ade Garc\u00eda Colomo.<\/p>\n

Junto a la UCM, en el trabajo participan la Universidad Polit\u00e9cnica de Madrid, el Instituto de Investigaci\u00f3n Sanitaria Galicia Sur y\u00a0el Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos de Madrid.<\/p>\n

Referencia:\u00a0<\/p>\n

Garc\u00eda-Colomo, A., L\u00f3pez-Sanz, D., Taguas, I.\u00a0et al.\u00a0\u00abEffects of Alzheimer\u2019s disease plasma marker levels on multilayer centrality in healthy individuals\u00bb.\u00a0Alz Res Therapy.<\/p>","protected":false},"excerpt":{"rendered":"

Un equipo de investigaci\u00f3n liderado por la Universidad Complutense de Madrid ha identificado la asociaci\u00f3n entre la demanda de regiones cerebrales clave para facilitar y coordinar el flujo de informaci\u00f3n entre el resto de \u00e1reas y altos niveles de marcadores en sangre de patolog\u00eda de la enfermedad de Alzh\u00e9imer (EA) en individuos que a\u00fan no […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-40711","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nDetectan cambios en regiones cerebrales en individuos con alzh\u00e9imer y alta carga patol\u00f3gica - 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