{"id":87705,"date":"2025-03-26T17:28:05","date_gmt":"2025-03-26T16:28:05","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/nuevo-mecanismo-de-regeneracion-rapida-del-higado-a-traves-del-glutamato\/"},"modified":"2025-03-26T17:28:05","modified_gmt":"2025-03-26T16:28:05","slug":"nuevo-mecanismo-de-regeneracion-rapida-del-higado-a-traves-del-glutamato","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/nuevo-mecanismo-de-regeneracion-rapida-del-higado-a-traves-del-glutamato\/","title":{"rendered":"Nuevo mecanismo de regeneraci\u00f3n r\u00e1pida del h\u00edgado a trav\u00e9s del glutamato"},"content":{"rendered":"

El h\u00edgado, esencial para la digesti\u00f3n, el metabolismo y la eliminaci\u00f3n de toxinas, es uno de los pocos \u00f3rganos que tiene la capacidad de regenerarse cuando sufre una lesi\u00f3n. Pero deja de recuperarse en enfermedades con da\u00f1o hep\u00e1tico cr\u00f3nico, como la cirrosis.<\/p>\n

El h\u00edgado es de los pocos \u00f3rganos capaz de regenerarse tras una lesi\u00f3n<\/p>\n

Ahora, un estudio liderado por el Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO) y publicado hoy<\/a> en la revista Nature, revela un mecanismo r\u00e1pido que tiene el h\u00edgado para regenerarse, y que se activa gracias al glutamato.<\/p>\n

Los resultados, de momento solo probados en ratones, muestran que la suplementaci\u00f3n nutricional con este amino\u00e1cido favorece la recuperaci\u00f3n de c\u00e9lulas hep\u00e1ticas. Esto beneficiar\u00eda a pacientes con da\u00f1o hep\u00e1tico grave y cr\u00f3nico, tambi\u00e9n los que se recuperan de una cirug\u00eda en el h\u00edgado o los que esperan un trasplante.<\/p>\n

<\/a><\/p>\n

Multiplicaci\u00f3n de c\u00e9lulas sanas<\/h2>\n

Nabil Djouder, uno de los autores del estudio, explica a SINC que la regeneraci\u00f3n del h\u00edgado no ocurre desde cero, sino que consiste en \u201cla sustituci\u00f3n de las c\u00e9lulas hep\u00e1ticas da\u00f1adas por aquellas que quedan sanas en el h\u00edgado\u201d.\u00a0<\/p>\n

El pico de regeneraci\u00f3n del h\u00edgado se alcanza entre las 48 y las 72 horas tras la lesi\u00f3n<\/p>\n

\u201cEl proceso de regeneraci\u00f3n hep\u00e1tica est\u00e1 altamente coordinado y es bastante r\u00e1pido. Cuando una parte del \u00f3rgano se lesiona o se extirpa, las c\u00e9lulas hep\u00e1ticas restantes comienzan a multiplicarse para restaurar el tejido perdido, y el resultado es visible incluso\u00a030 minutos despu\u00e9s de la extirpaci\u00f3n\u201d, afirma el investigador.<\/p>\n

El pico de regeneraci\u00f3n se alcanza a las 48 horas de la lesi\u00f3n en ratones y entre las 48 y 72 horas en humanos,\u00a0dependiendo de la magnitud de la lesi\u00f3n, la salud general del paciente o enfermedades previas.<\/p>\n

<\/a><\/p>\n

Glutamato y m\u00e9dula \u00f3sea<\/h2>\n

Lo que revela este nuevo trabajo es el mecanismo molecular de esta regeneraci\u00f3n y el papel crucial del glutamato, que colabora con la m\u00e9dula \u00f3sea.<\/p>\n

Los macr\u00f3fagos son los responsables de estimular la regeneraci\u00f3n del h\u00edgado<\/p>\n

Seg\u00fan explica Djouder, el glutamato interacciona con la m\u00e9dula que se encuentra dentro de los huesos y donde se originan las c\u00e9lulas inmunitarias. \u201cAs\u00ed, activa unas c\u00e9lulas inmunes llamadas monocitos, que viajan por la sangre hasta el h\u00edgado y se transforman en macr\u00f3fagos\u201d, a\u00f1ade. Estos macr\u00f3fagos son los responsables de estimular la regeneraci\u00f3n del h\u00edgado, y provocan que las c\u00e9lulas de este \u00f3rgano se multipliquen.<\/p>\n

Aunque este trabajo se ha llevado a cabo en ratones, los autores realizaron an\u00e1lisis bioinform\u00e1ticos y cultivos de c\u00e9lulas y observaron que los mecanismos son similares en seres humanos.<\/p>\n

Para comprobarlo, el siguiente paso ser\u00e1 trasladar la investigaci\u00f3n a personas a trav\u00e9s de un ensayo cl\u00ednico, aunque Djouder pide cautela. \u201cSi bien los procesos de regeneraci\u00f3n hep\u00e1tica son muy similares en ratones y humanos, la velocidad y la extensi\u00f3n de la regeneraci\u00f3n pueden variar\u201d, concluye.<\/p>\n

Referencia:<\/p>\n

Djouder, N. Rigual, M. \u201cMacrophages harness hepatocyte glutamate to boost liver regeneration\u201d.\u00a0Nature<\/a>\u00a0(2025)<\/p>","protected":false},"excerpt":{"rendered":"

El h\u00edgado, esencial para la digesti\u00f3n, el metabolismo y la eliminaci\u00f3n de toxinas, es uno de los pocos \u00f3rganos que tiene la capacidad de regenerarse cuando sufre una lesi\u00f3n. Pero deja de recuperarse en enfermedades con da\u00f1o hep\u00e1tico cr\u00f3nico, como la cirrosis. El h\u00edgado es de los pocos \u00f3rganos capaz de regenerarse tras una lesi\u00f3n […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-87705","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nNuevo mecanismo de regeneraci\u00f3n r\u00e1pida del h\u00edgado a trav\u00e9s del glutamato - bip4ex<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/helloproject.es\/vigilancia\/nuevo-mecanismo-de-regeneracion-rapida-del-higado-a-traves-del-glutamato\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuevo mecanismo de regeneraci\u00f3n r\u00e1pida del h\u00edgado a trav\u00e9s del glutamato\" \/>\n<meta property=\"og:description\" content=\"El h\u00edgado, esencial para la digesti\u00f3n, el metabolismo y la eliminaci\u00f3n de toxinas, es uno de los pocos \u00f3rganos que tiene la capacidad de regenerarse cuando sufre una lesi\u00f3n. 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