{"id":98722,"date":"2025-04-11T10:28:35","date_gmt":"2025-04-11T09:28:35","guid":{"rendered":"https:\/\/helloproject.es\/vigilancia\/identifican-una-nueva-diana-terapeutica-para-el-cancer-de-pulmon\/"},"modified":"2025-04-11T10:28:35","modified_gmt":"2025-04-11T09:28:35","slug":"identifican-una-nueva-diana-terapeutica-para-el-cancer-de-pulmon","status":"publish","type":"post","link":"https:\/\/helloproject.es\/vigilancia\/identifican-una-nueva-diana-terapeutica-para-el-cancer-de-pulmon\/","title":{"rendered":"Identifican una nueva diana terap\u00e9utica para el c\u00e1ncer de pulm\u00f3n"},"content":{"rendered":"

Un estudio internacional liderado por el CSIC ha identificado a la prote\u00edna SOS1, un activador universal de prote\u00ednas RAS en c\u00e9lulas de mam\u00edferos, como una nueva diana terap\u00e9utica en adenocarcinoma de pulm\u00f3n, el tumor m\u00e1s frecuente en este \u00f3rgano, y en otros c\u00e1nceres dependientes de oncogenes RAS mutados.\u00a0Los resultados se han publicado en la revista PNAS.<\/p>\n

<\/a><\/p>\n

RAS es una familia de prote\u00ednas cruciales en la se\u00f1alizaci\u00f3n celular, que act\u00faan como interruptores moleculares para regular procesos como la supervivencia, la proliferaci\u00f3n y la diferenciaci\u00f3n celular.<\/h2>\n

Las mutaciones en KRAS son comunes en c\u00e1nceres de pulm\u00f3n, p\u00e1ncreas y colon<\/p>\n

Los oncogenes\u00a0RAS mutados\u00a0son variantes de las prote\u00ednas RAS que, debido a mutaciones gen\u00e9ticas, est\u00e1n constantemente activados, lo que promueve el crecimiento y la proliferaci\u00f3n celular descontrolada.<\/p>\n

Cuando se producen mutaciones en genes como KRAS, las prote\u00ednas RAS no responden a las se\u00f1ales de desactivaci\u00f3n, lo que favorece el desarrollo de tumores. Las mutaciones en KRAS son comunes en c\u00e1nceres de pulm\u00f3n, p\u00e1ncreas y colon.<\/p>\n

<\/a><\/p>\n

Ratones con adenocarcinoma de pulm\u00f3n<\/h2>\n

En este estudio, los investigadores han probado en ratones con adenocarcinoma de pulm\u00f3n, causado por el oncog\u00e9n mutado KRASG12D, atacar a las prote\u00ednas relacionadas con el desarrollo de tumores.<\/p>\n

Espec\u00edficamente, han estudiado la inhibici\u00f3n farmacol\u00f3gica de la prote\u00edna SOS1 utilizando el inhibidor BI-3406 (patentado por la compa\u00f1\u00eda Boehringer Ingelheim) que produce un\u00a0bloqueo del desarrollo tumoral.<\/p>\n

<\/p>\n

La\u00a0inhibici\u00f3n\u00a0farmacol\u00f3gica de la\u00a0prote\u00edna\u00a0SOS1\u00a0mediante el inhibidor\u00a0BI-3406\u00a0produce un\u00a0bloqueo del desarrollo tumoral, seg\u00fan el estudio<\/p>\n

Dr. Fernando C. Baltan\u00e1s, autor del estudio
\n<\/p>\n

Las observaciones finales son similares a las previamente demostradas mediante la ablaci\u00f3n gen\u00e9tica de esta misma prote\u00edna en una investigaci\u00f3n desarrollada en el laboratorio del Centro de Investigaci\u00f3n de C\u00e1ncer (CIC), dirigido por el profesor Eugenio Santos.<\/p>\n

La ablaci\u00f3n gen\u00e9tica es un procedimiento experimental que consiste en eliminar o interrumpir un gen espec\u00edfico. En este estudio paralelo, se utiliz\u00f3 esta t\u00e9cnica para comprobar el impacto de eliminar el gen SOS1 y para validar el papel crucial de esta prote\u00edna en el desarrollo tumoral.\u00a0Finalmente, se compararon sus efectos con los resultados obtenidos en el tratamiento con el inhibidor BI-3406.<\/p>\n

<\/a><\/p>\n

Una puerta abierta a terapias combinadas<\/h2>\n

Adem\u00e1s de mostrar baja toxicidad sist\u00e9mica en los ratones, el tratamiento con BI-3406 no s\u00f3lo\u00a0reduce la carga tumoral\u00a0intr\u00ednseca. Es decir, caracter\u00edsticas biol\u00f3gicas del tumor, como mutaciones, perfil de expresi\u00f3n g\u00e9nica, etc.), sino que tambi\u00e9n modula el\u00a0microambiente\u00a0tumoral de manera\u00a0beneficiosa.<\/p>\n

Los resultados revelan tambi\u00e9n que la combinaci\u00f3n de BI-3406 con un inhibidor (MRTX1133) dirigido espec\u00edficamente contra la mutaci\u00f3n KRASG12D produce efectos antitumorales sin\u00e9rgicos, lo que sugiere un potencial significativo para el desarrollo de terapias combinadas m\u00e1s efectivas contra el c\u00e1ncer de pulm\u00f3n.<\/p>\n

Los inhibidores de SOS1 podr\u00edan ser componentes v\u00e1lidos en\u00a0m\u00faltiples\u00a0terapias antitumorales dirigidas<\/p>\n

Fernando C. Baltan\u00e1s, uno de los autores principales del nuevo estudio, resalta que \u201clos resultados obtenidos en esta investigaci\u00f3n confirman que SOS1 es una diana terap\u00e9utica viable en una variedad de c\u00e1nceres dependientes de los oncogenes RAS\u201d.<\/p>\n

Esto significa que los inhibidores de SOS1 podr\u00edan ser componentes v\u00e1lidos en\u00a0m\u00faltiples\u00a0terapias antitumorales dirigidas.<\/p>\n

<\/a><\/p>\n

Monoterapia y combinaci\u00f3n de f\u00e1rmacos<\/h2>\n

\u201cAdem\u00e1s, identificamos una ventana terap\u00e9utica para desarrollar una intervenci\u00f3n farmacol\u00f3gica apropiada con inhibidores de SOS1, tanto en monoterapia como en una combinaci\u00f3n de f\u00e1rmacos dirigidos contra mutaciones espec\u00edficas de KRAS\u201d, termina exponiendo el mismo investigador.<\/p>\n

El estudio ha sido realizado en colaboraci\u00f3n con investigadores de la Universidad de Torino (Italia) y la farmac\u00e9utica Boehringer Ingelheim . Ha contado con financiaci\u00f3n, entre otras instituciones, del CIBER del c\u00e1ncer (CIBERONC) del Instituto de Salud Carlos III, el Ministerio de Ciencia, Innovaci\u00f3n y Universidades, la Asociaci\u00f3n In\u00e9s de Pablo Llorens, la Fundaci\u00f3n Eugenio Rodr\u00edguez Pascual y la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (mediante el programa Stop Ras Cancers).<\/p>\n

Referencia:<\/p>\n

Baltan\u00e1s, F.C et al. \u201cInhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with KRASG12D inhibitor in KRASmut LUAD\u201d.\u00a0PNAS<\/a>\u00a0(2025).<\/p>","protected":false},"excerpt":{"rendered":"

Un estudio internacional liderado por el CSIC ha identificado a la prote\u00edna SOS1, un activador universal de prote\u00ednas RAS en c\u00e9lulas de mam\u00edferos, como una nueva diana terap\u00e9utica en adenocarcinoma de pulm\u00f3n, el tumor m\u00e1s frecuente en este \u00f3rgano, y en otros c\u00e1nceres dependientes de oncogenes RAS mutados.\u00a0Los resultados se han publicado en la revista […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-98722","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"\nIdentifican una nueva diana terap\u00e9utica para el c\u00e1ncer de pulm\u00f3n - 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